Manel Esteller (Sant Boi de Llobregat, Barcelona, Catalonia, Spain, 1968) graduated in Medicine with Honours from the Universitat de Barcelona in 1992, where he also obtained his PhD degree in molecular genetics in 1996. He was an Invited Researcher at the School of Biological and Medical Sciences at the University of St. Andrews (Scotland, UK). From 1997 to 2001, Dr. Esteller was a researcher at the Johns Hopkins University and School of Medicine (Baltimore, USA) where he was decisive in establishing promoter hypermethylation of tumour suppressor genes as a common hallmark of all human tumours. From October 2001 to September 2008 he was CNIO Cancer Epigenetics Laboratory’s leader. Dr Esteller is Director of the Cancer Epigenetics and Biology Program (PEBC) of the Bellvitge Biomedical Research Institute (IDIBELL) and Chairman of Genetics at the School of Medicine in the University of Barcelona. He has been elected as Director of the Josep Carreras Research Institute (IJC).