Manuel Serrano obtained his PhD in 1991 for his research at the Centre for Molecular Biology (CSIC/UAM, Madrid)) under the supervision of M. Salas and J.M. Hermoso. From 1992 to 1996 he worked as a Postdoctoral Fellow in the laboratory of D. Beach at the Cold Spring Harbor Laboratory, New York, USA. In 1997, he returned to Spain to start his own research group at the Spanish National Biotechnology Centre (CSIC, Madrid). He moved to the Spanish National Cancer Research Centre (Madrid) in 2003 to lead the Tumour Suppression Group, where he also served as Director of the Molecular Oncology Programme (2012-2017). In May 2017, he relocated to the Institute for Biomedical Research-IRB Barcelona to establish the Cellular Plasticity and Disease Group within the Molecular Medicine Research Programme. He has accomplished important scientific contributions to the understanding of Ageing from different perspectives: Cancer & Ageing, Metabolism & Ageing, Regeneration & Ageing.