Gian Gaetano Tartaglia – Centre de Regulació Genòmica (CRG)

We analyzed protein-RNA networks and identified properties of RNA attracting proteins in large assemblies. We found that trinucleotide repeats in the FMR1 gene attract several proteins including the splicing factor TRA2A that aggregates in Fragile X-associated Tremor/Ataxia Syndrome (FXTAS).


Cid-Samper F, Gelabert-Baldrich M, Lang B, Lorenzo-Gotor N, Ponti RD, Severijnen LWFM, Bolognesi B, Gelpi E, Hukema RK, Botta-Orfila T, Tartaglia GG 2018, ‘An Integrative Study of Protein- RNA Condensates Identifies Scaffolding RNAs and Reveals Players in Fragile X-Associated Tremor/Ataxia Syndrome’, Cell Rep. 25(12):3422-3434.e7.