Andrea Cerutti

Institut Hospital del Mar d'Investigacions Mèdiques (IMIM)

Life & Medical Sciences

Andrea Cerutti, MD, is an ICREA Research Professor since 2010 and leads the B Cell Biology Group at PRBB-IMIM. He serves as reviewer for the European Research Council, the National Institutes of Health and several biomedical and immunology journals, including Science, Nature, Immunity, Nature Immunology, Nature Medicine, Nature Communications, The Journal of Experimental Medicine and The Journal of Immunology. He is a member of The American Society for Clinical Investigation and The Henry Kunkel Society, as well as Associate Editor of Mucosal Immunology. He organized two Keystone Symposium meetings on B cells and published over 100 research articles in top-ranked immunology journals and lectures in international meetings as well as American and European universities.

Research interests

My group studies the cellular and signaling networks underlying immunoglobulin (Ig) heavy chain class switching and V(D)J gene somatic hypermutation, two B cell-mediated processes essential for the generation of immune diversity and protection. We are particularly interested in the mechanisms by which the innate immune system interacts with B cells and in the strategies utilized by pathogens to evade Ig production systemically and at mucosal sites of entry. Our research is relevant to infections, inflammation, autoimmunity, immunodeficiencies and vaccine development.

Selected publications

– Magri G & Cerutti A 2016, ‘A Touch of Youth in Gut Microbiota Development’, Immunity, 45, 1, 12 – 14.

– Chorny A, Casas-Recasens S, Sintes J, Shan M, Polentarutti N, García-Escudero R, Walland AC, Yeiser JR, Cassis L, Carrillo J, Puga I, Cunha C, Bastos H, Rodrigues F, Lacerda JF, Morais A, Dieguez-Gonzalez R, Heeger PS, Salvatori G, Carvalho A, Garcia-Sastre A, Blander JM, Mantovani A, Garlanda C & Cerutti A 2016, ‘The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells’, Journal of Experimental Medicine, vol 213, no. 10, pp 2167-2185.

Selected research activities

Co-Organizer, B cells at the intersection between innate and adaptive immunity (E3), Keystone Symposia, May 29—June 2, 2016