Patrick Aloy

Institut de Recerca Biomèdica de Barcelona

Life & Medical Sciences

Dr Patrick Aloy is an ICREA Research Professor and Principal Investigator of the Structural Systems Biology lab at the IRB. He has a BSc in Biochemistry and a MSc in Biotechnology from the Univ. Autònoma de Barcelona, Spain, and spent six years as postdoctoral researcher and staff scientist at the European Molecular Biology Laboratory, Heidelberg, Germany. For fifteen years, Dr Aloy has been developing and implementing new technologies and algorithms, applying state-of-the-art methods to specific problems and bridging the gap between theoretical models and experiments in different disciplines. In the last years, he has pioneered system-scale analyses of macromolecular assemblies and networks using high-resolution three-dimensional structures, which has become a new discipline in structure prediction. Dr Aloy has over 100 publications in first-rate journals, with over 9500 citations and remarkable press coverage, illustrating the scientific and social impact of the work.

Research interests

The main goal of my laboratory is to combine computational and structural biology with interaction discovery experiments to unveil the basic wiring architecture of physio-pathological pathways. It is our believe that a deeper knowledge of the global topology of interactome networks related to human disease will have important bearings in the discovery of new drug targets and biomarkers, optimisation of preclinical models and understanding how biological networks change from the healthy state to disease.

Selected publications

- Jaeger S, Igea A, Arroyo R, Alcalde V, Cánovas B, Orozco M, Nebreda ÁR & Aloy P 2017, 'Quantification of pathway crosstalk reveals nvel synergistic drug combinations for breast cancer', Cancer Research, 77, 2, 459 - 469.

- Mateo L, Guitart-Pla O, Pons C, Duran-Frigola M, Mosca R & Aloy P 2017, 'A PanorOmic view of personal cancer genomes', Nucleic Acids Research, 45, W1, W195-W200.

- Duran-Frigola M, Siragusa L, Ruppin E, Barril X, Cruciani G & Aloy P 2017, 'Detecting similar binding pockets to enable systems polypharmacology', Plos Computational Biology, 13, 6, e1005522.

- Duran-Frigola M, Mateo L & Aloy P 2017, 'Drug repositioning beyond the low-hanging fruits', Current Opinion in Systems Biology, 3:95-102.

- Weile J, Sun S, Cote AG, Knapp J, Verby M, Mellor JC, Wu J, Pons C, Wong C,  van Lieshout N, Yang F, Tasan M, Tan G, Yang S, Fowler DM, Nussbaum R, Bloom JD, Vidal M, Hill DE, Aloy P & Roth FP 2017, 'A framework for exhaustively mapping of human missense variants', Mol Syst Biol. 13: 957

Selected research activities

Organizer of the Structural Coputational Biology session of the 42nd FEBS Congress. Sep 2017. Jerusalem (IL).