Salvador A. Benitah

Institut de Recerca Biomèdica de Barcelona

Life & Medical Sciences

Salvador Aznar Benitah is a group leader at the Institute for Research in Biomedicine (IRB Barcelona). He holds a BSc/MSc in Biochemistry from the University of McGill (Montreal, Canada), from where he moved to the Biomedical Research Institute (Madrid, Spain) to obtain a PhD in Molecular Biology. His professional career continued at the London Research Institute (Cancer Research UK) in the laboratory of Prof. Fiona Watt where he acquired extensive knowledge on adult stem cells. He started as a Junior ICREA researcher at the CRG in 2007 where he studied the role of adult stem cells in tissue homeostasis and cancer. Since September 2012 he is an ICREA Research Professor. In September 2013 he became a Senior Researcher in the Oncology Department at the Institute for Research in Biomedicine (IRB Barcelona).

Research interests

Our global aim is to characterize the molecular pathways that regulate the behaviour of normal stem cells during homeostasis, and how they become deregulated during carcinogenesis and ageing. Research Lines: - What intrinsic mechanisms regulate adult stem cell function, and how are they deregulated during ageing and cancer? - How do adult stem cells communicate with their local environment and how is the system coordinated to dictate stem cell function? - What systemic cues communicate with adult stem cells and how do distant adult stem cells coordinate their function at the level of the whole organism? - How does deregulation of pathways that control stem cell behaviour contribute to the maintenance and progression of carcinomas?

Selected publications

- Solanas G, Peixoto FO, Perdiguero E, Jardí M, Ruiz-Bonilla V, Datta D, Symeonidi A, Castellanos A, Welz PS, Caballero JM, Sassone-Corsi P, Muñoz-Cánoves P & Benitah SA 2017, 'Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress', Cell, 170(4):678-692.

- Sato S, Solanas G, Peixoto FO, Bee L, Symeonidi A, Schmidt MS, Brenner C, Masri S, Benitah SA* & Sassone-Corsi P* 2017, 'Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging', Cell, 170(4):664-677 (*co-corresponding)

- Pascual G, Avgustinova A, Mejetta S, Martín M, Castellanos A, Attolini CS, Berenguer A, Prats N, Toll A, Hueto JA, Bescós C, Di Croce L & Benitah SA 2017, 'Targeting metastasis-initiating cells through the fatty acid receptor CD36', Nature, 541(7635):41-45 (Article)

- Rinaldi L, Avgustinova A, Martin M, Datta D, Solanas G, Neus P & Benitah SA 2017, 'Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-gamma', Elife, 6, e21697.

- Besson V, Kyryachenko S, Janich P, Benitah SA, Marazzi G & Sassoon D 2017, 'Expression Analysis of the Stem Cell Marker Pw1/Peg3 Reveals a CD34 Negative Progenitor Population in the Hair Follicle', Stem Cells,&

Selected research activities

Bank Caja Rural National Award for Life Sciences

City of Barcelona Award for Life Sciences

Organizer of the Epigenetics in Skin Symposium (Salzburg)