Pia Cosma

Centre de Regulació Genòmica

Life & Medical Sciences

ICREA Research Professor and Senior Scientist at Centre for Genomic Regulation (CRG), Barcelona, since Sep. 2010. From 2009-2015 Honorary Associate Investigator at CNR . 2003-2010 Associate Investigator at TIGEM, Naples. 2004-2010 Lecturer at European School of Molecular Medicine. 1997-2000 Marie Curie Postdoc at IMP, Vienna. PhD in Cellular and Molecular Genetics, Univ. Federico II of Naples, 2000. Visiting Scientist in many Universities in USA. She has given invited talks at major international conferences and Research Institutes. She has been awarded several prizes including: EMBO Young Investigator (YIP) in 2003, Marie Curie Excellence Award in 2005, "Vanguardia de la Ciència" prize in 2014 and City of Barcelona prize in 2015. She is Order of Merit of the Italian Republic; grade: Knight in 2007. She is ERC Starting Grant awardee, 2009 and HFSP Grant awardee, 2010. She was elected EMBO Member in 2010. She is coordinator of H2020 FET-Open from 2016.

Research interests

Main interests of Cosma's group are to dissect mechanisms and factors controlling somatic cell reprogramming and tissue regeneration in mammalians. We showed that activation of the Wnt/ß-catenin signalling pathway enhances reprogramming of somatic cells after their fusion with embryonic stem cells. We are dissecting gene networks and reprogramming factors controlled by the activation of Wnt/ß-catenin pathway. Furthermore, by using super resolution microscopy we are investigating on the remodelling of the chromatin fiber during the reprograming process. Remarkably, the activation of Wnt pathway also controls regeneration in response to damage in lower and higher vertebrates. Our goal is to determine whether activation of Wnt/ß-catenin signalling controls cell-fusion-mediated regeneration in mammals. We recently showed that in vivo reprogramming of neurons and hepatocytes after fusion with hematopoietic stem and progenitor cells is a mechanism for tissue regeneration.

Selected publications

- Pedone E, Oltenau V-A, Marucci L, ... & Cosma MP 2017, 'Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration',Cell Reports, 18, 107–121 

- De Jaime-Soguero A, Aulicino F, Ertaylan G, Griego A, Cerrato A, Tallam A, del Sol A,*Cosma MP & *Lluis F 2017, 'Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus', Plos Genetics, 13, 3, e1006682. *co-last and co-corresponding authors. 

- Theka I, Sottile F, Aulicino F, Castells Garcia A & Cosma MP 2017, 'Reduced expression of Paternally Expressed Gene-3 enhances somatic cell reprogramming through mitochondrial activity perturbation', Scientific Reports, 7, 9705.

- Ricci MA, *Cosma MP & *Lakadamyali M 2017, 'Super resolution imaging of chromatin in pluripotency, differentiation, and reprogramming', Current Opinion In Genetics & Development, 46, 186 - 193. * co-last and co-corresponding authors

- Cosma MP 2017, 'The nanoscale structure of chromatin fibers in somatic and stem cells', Molecular Cytogenetics, 10.

- Kieffer-Kwon KR, Nimura K, ....Cosma MP,....  Casellas R 2017, 'Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation', Molecular Cell Aug 17;67(4):566-578.e10.

Selected research activities

Invited talks :

- 3rd International Summit of Stem Cell Therapy for Eye diseases/Chongqing, China 

- Environmental epigenetic, KAUST, Saudi Arabia

- The 3D/4D organization of chromatin, Barcelona 

- SIBBM conference, Milan, Italy

- Guangzhou Institutes of Biomedicine and Health, China

- University of Zurich, Switzerland

- Humanitas, Milan, Italy

- GMI, Vienna, Austria