Eduardo Eyras

Universitat Pompeu Fabra

Life & Medical Sciences

E Eyras is ICREA Research Professor since January 2005. After graduating in Physics (U. of Granada, 1995) he did a PhD in Mathematics (U. of Groningen, The Netherlands, 1999) and postdoc (U. of Cambridge, UK)  (1999-2001). In 2001, Eyras joined the Wellcome Trust Sanger Institute, Cambridge, UK (2001-2004), where he worked on methods for alternative splicing prediction and participated in the analyses of the human, mouse and rat genomes. He has also contributed to the analyses of alternative splicing in the chicken and cow genome genomes and since 2007, he has been organizer of the RNA workshop of the ISMB conference. In 2008 was awarded a Young Investigator Grant of the EURASNET network, and in 2013 he was a visiting professor at the U. of Toronto. E. Eyras leads a research group on Computational RNA Biology and Disease and teaches Machine Learning in genomics in the Masters of Bioinformatics for Health of the UPF.

Research interests

Our group works on the development of computational tools to study mechanisms of RNA processing and its role in disease. We develop computational tools to identify RNA splicing signatures of therapeutic vulnerability in rare diseases and cancer, and develop new algorithms to facilitate the systematic implementation of long-read RNA sequencing in precision medicine.

Selected publications

- Cifdaloz M, Osterloh L, Graña O, Riveiro-Falkenbach E, Ximénez-Embún P, Muñoz J, Karras P, Olmeda D, Miñana B, Gómez-López G, Cañon E, Eyras E, Guo H, Kappes F, Ortiz-Romero PL, Rodríguez-Peralto JL, Megías D, Valcárcel J & Soengas MS 2017, 'Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1', Nature Communications, 8(1):2249.

- Climente-Gonzalez H, Porta-Pardo E, Godzik A & Eyras E 2017, 'The functional impact of Alternative splicing in cancer', Cell Reports, 20(9):2215-2226.

- Singh B & Eyras E 2017, 'The role of alternative splicing in cancer'. Transcription, 8(2):91-98. Review. 

- Rodor J, FitzPatrick DR, Eyras E, & Cáceres JF 2017, 'The RNA-binding landscape of RBM10 and its role in alternative splicing regulation in models of mouse early development', RNA Biology, 14(1):45-57.

- Pagès A, Dotu I, Pallarés-Albanell J, Marti E, Guigo R & Eyras E 2017, 'The discovery potential of RNA processing profiles', Nucleic Acids Research, Nov 16 

- Middleton R, Gao D, Thomas A, Singh B, Au A, Wong JJL, Bomane A, Cosson B, Eyras E, Rasko JE & Ritchie W 2017, 'IRFinder: assessing the impact of intron retention on mammalian gene expression', Genome Biology, 18, 51.

Selected research activities

- Organizer of the RNA track of the ISMB (Intelligent Systems for Molecular Biology) 2017 Conference.  Prague, July 2017. (

- Keynote speaker at the conference Bermuda Principles – Impact on splicing. Bermuda. Feb 2017. The functional impact of differential splicing in cancer. 

- Invited seminars at Dundee University (UK), Newcastle University (UK), Cordoba University, and IMIM Cancer Program.

- Member of the RNA GECIP (Genomics England Clinical Interpretation Partnership) and of the TCGA Pancancer Consortium - Splicing Group.

- Associate Editor of BMC Genomics and of Frontiers in Molecular Biosciences – Ribonucleoprotein Networks.