Toni Gabaldón

Centre de Regulació Genòmica

Life & Medical Sciences

I'm a biochemist and molecular biologist by training (Universities of Valencia and Mainz). After several years working on a molecular biology lab, and attracted by the emerging fields of genomics and bioinformatics, in 2001 I moved to the comparative genomics group of Martijn Huynen in the NCMLS, The Netherlands. In 2005, I obtained a PhD in Medical Sciences (Radbout University Nijmegen), and then moved, thanks to an EMBO fellowship, to the bioinformatics department at CIPF (Valencia). In September 2008 I started my own group in the Bioinformatics and Genomics department at CRG. In 2013 I was awarded an ERC starting grant and an ICREA research professorship. In 2017 I was awarded the ERC consolidator Grant and the Margaret Dayhoff Award. I have always used an evolutionary perspective to address different biological questions. I am not only interested in understanding how complex biological systems work, but also how they have come to be as they are.

Research interests

My main research interest is to understand the complex relationships between genome sequences and phenotypes and how these two features evolve within and across species. I generally use large-scale phylogenetics and molecular evolution approaches that allow looking at the evolution of genomes from the perspective of all of their genes, and apply these analyses to a variety of biological questions related to the evolution and function of biological communities, organisms, organelles, pathways, and families of protein-coding and non-coding genes. I have a special interest in understanding processes related to human pathogenesis. Through collaborations with experimental groups, I apply comparative genomics to discover new mechanisms and genes involved in interesting processes, especially those of clinical relevance. Given our exposure to new types and scales of data, my group has had the need to develop novel bioinformatics tools to fill in existing gaps.

Selected publications

- Mathers TC, Chen Y, Kaithakottil G, Legeai F, Mugford ST, Baa-Puyoulet P, Bretaudeau A, Clavijo B, Colella S, Collin O, Dalmay T, Derrien T, Feng H, Gabaldon T, Jordan A, Julca I, Kettles GJ, Kowitwanich K, Lavenier D, Lenzi P, Lopez-Gomollon S, Loska D, Mapleson D, Maumus F, Moxon S, Price DRG, Sugio A, van Munster M, Uzest M, Waite D, Jander G, Tagu D, Wilson ACC, van Oosterhout C, Swarbreck D & Hogenhout SA 2017, 'Rapid transcriptional plasticity of duplicated gene clusters enables a clonally reproducing aphid to colonise diverse plant species', Genome Biology, 18(1):27.

- Figueiro HV, Li G, Trindade FJ, Assis J, Pais F, Fernandes G, Santos SHD, Hughes GM, Komissarov A, Antunes A, Trinca CS, Rodrigues MA, Linderoth T, Bi K, Silveira L, Azevedo FCC, Kantek D, Ramalho E, Brassaloti RA, Villela PMS, Nunes ALV, Teixeira RHF, Morato RG, Loska D, Saragueta P, Gabaldon T, Teeling EC, O'Brien SJ, Nielsen R, Coutinho LL, Oliveira G, Murphy WJ &Eizirik E 2017, 'Genome-wide signatures of complex introgression and adaptive evolution in the big cats', Science Advances, 3, 7, e1700299.

- Masgrau A, Battola A, Sanmartin T, Pryszcz LP, Gabaldon T & Mendoza M 2017, 'Distinct roles of the polarity factors Boi1 and Boi2 in the control of exocytosis and abscission in budding yeast', Molecular Biology Of The Cell, 28, 22, 3082 - 3094.

- Bravo-Ruiz G, Sassi AH, Marcet-Houben M, Di Pietro A, Gargouri A, Gabaldón T & Roncero MIG 2017, 'Regulatory Mechanisms of a Highly Pectinolytic Mutant of Penicillium occitanis and Functional Analysis of a Candidate Gene in the Plant Pathogen Fusarium oxysporum', Front Microbiol. 8:1627.

-  Cillingová A, Zeman I, Tóth R, Neboháčová M, Dunčková I, Hölcová M, Jakúbková M, Gérecová G, Pryszcz LP, Tomáška Ľ, Gabaldón T, Gácser A & Nosek J 2017, 'Eukaryotic transporters for hydroxyderivatives of benzoic acid',Sci Rep. 7(1):8998.