Gerardo Jiménez

Institut de Biologia Molecular de Barcelona

Life & Medical Sciences

Gerardo Jiménez graduated in biology from the Universitat de Barcelona in 1988. He performed his doctoral studies at the Leukaemia Research Fund in London and at the Department of Biochemistry of the Universitat de Barcelona, working on the structure and regulation of mammalian globin gene loci. After receiving his PhD degree in 1993, he worked as a postdoctoral fellow at Cancer Research UK, both in Oxford and in London. Since then, his research interests have focused on the transcriptional and cell signaling mechanisms controlling gene expression, mainly using Drosophila as a model system. After his postdoctoral training, he moved to the Institut de Biologia Molecular de Barcelona-CSIC, where he is principal investigator since 2002. He joined ICREA in 2003.

Research interests

During animal development, the differentiation of cells, tissues and organs is tightly regulated through specific gene expression programs. Our group is particularly interested in studying the transcriptional and cell signaling mechanisms responsible for this control. Using Drosophila as a model system, we have been dissecting the activities of repressor and co-repressor factors, as well as the responses induced by receptor tyrosine kinase (RTK) pathways during pattern formation and differentiation. One emerging theme has been the identification of the Capicua transcriptional repressor as a general sensor targeted by multiple RTK-initiated signals. Because the molecules and pathways that we study are conserved in evolution, our results have direct implications for human biology and disease.

Selected publications

- Forés M, Simón-Carrasco L, Ajuria L, Samper N, González-Crespo S, Drosten M, Barbacid M & Jiménez G 2017, 'A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer', PLoS Genet., 13: e1006622. 

- Simón-Carrasco L, Graña O, Salmón M, Jacob HKC, Gutierrez A, Jiménez G, Drosten M & Barbacid M 2017, 'Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma', Genes Dev., 31: 1456-1468. 

- Forés M, Papagianni A, Rodríguez-Muñoz L & Jiménez G 2017, 'Using CRISPR-Cas9 to study ERK signaling in Drosophila', Methods Mol Biol, 1487, 353-365.

- Jiménez G (ed) 2017, 'ERK Signaling: Methods and Protocols', Methods Mol Biol Series, vol. 1487, Springer, New York.

Selected research activities

- Principal Investigator of research project “Transcriptional regulation by RTK signaling” funded by MINECO (2015-2017).

- Coordinator of research project “Molecular analysis of Capicua, a novel tumor suppressor involved in RTK signaling and transcriptional repression” funded by Fundació La Marató de TV3 (2014-2017).

- Director of PhD Thesis “Mecanismo de acción del factor represor Capicua, un sensor de señales Ras/MAPK”, by Marta Forés. Universitat de Barcelona, July 2017.

- Director of PhD Thesis “Dissecting the activities of Capicua, Dorsal and Groucho in Drosophila dorsoventral patterning”, by Aikaterini Papagianni. Universitat de Barcelona, September 2017.

- Invited speaker at Brain & Spine Institute (ICM), Hôpital Pitié Salpêtrière, Paris.

- Invited speaker at Institute for Research in Biomedicine (IRB), Barcelona.

- Grant evaluator for the Israel Science Foundation.

- Vice-director of Institut de Biologia Molecular de Barcelona (CSIC).