Pura Muñoz-Cánoves

Universitat Pompeu Fabra

Life & Medical Sciences

Pura Muñoz-Cánoves studied Pharmacology in the University of Valencia. She obtained her PhD in 1990 in the Autonomous University of Madrid for work carried out at The Scripps Research Institute (La Jolla, USA). She did postdoctoral work at the University of California-San Diego and The Scripps Research Institute, and in 1994 she joined the Cancer Research Institute in Barcelona as a postdoc, becoming an independent group leader in 1997. In 2002 her group moved to the Center for Genomic Regulation (CRG) in Barcelona, and she became a senior scientist in 2007 in that Institution. Late 2008 she moved to the Pompeu Fabra University (UPF) after becoming an ICREA Research Professor. Through the UPF, she holds a collaborative agreement with the Spanish National Center on Cardiovascular Research. Her research focuses on deciphering the mechanisms regulating skeletal muscle regeneration and growth, in physiology and disease.

Research interests

Our main objective is to understand the mechanisms regulating stem cell homeostasis and regenerative functions: how stem cells maintain quiescence, are activated, transit to proliferative expansion and differentiation, and finally self-renew, and how they interact with the external inflammatory environment. Research is specially focused on stem cells of skeletal muscle. Recent studies from the laboratory have shed light on 1) age-associated muscle decline and wasting (sarcopenia) and loss of stem-cell regenerative functions with aging; and 2) the physiopathology of muscular dystrophies, with a specific interest in the contribution of inflammation and fibrosis to dystrophy progression. These findings are relevant for regenerative medicine.

Selected publications

- Bengal E, Perdiguero E, Serrano AL & Muñoz-Cánoves P 2017, ‘Rejuvenating stem cells to restore muscle regeneration in aging.’ F1000Res. 25;6:76

- García-Prat L, Muñoz-Cánoves P & Martínez-Vicente M 2017, 'Monitoring Autophagy in Muscle Stem Cells'. Methods Mol Biol., 1556:255-280.

- Testoni G, Duran J, García-Rocha M, Vilaplana F, Serrano AL, (...) Muñoz-Cánoves P & Guinovart JJ. 2017, 'Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment', Cell Metab., 1:256-266

- Serrano AL & Muñoz-Cánoves P 2017, 'Fibrosis development in early-onset muscular dystrophies', Semin Cell Dev Biol, 64:181-190

- Garcia-Prat L &  Munoz-Canoves P 2017, 'Aging, metabolism and stem cells', Molecular And Cellular Endocrinology, 15;445:109-117

- Garcia-Prat L, Sousa-Victor P & Munoz-Canoves P 2017, 'Proteostatic and Metabolic Control of Stemness', Cell Stem Cell, 20:593-608

- Lopez-Luppo M, (...) Munoz-Cannoves P, Nacher V & Ruberte J. 2017, 'Cellular Senescence Is Associated With Human Retinal Microaneurysm Formation During Aging', Investigative Ophthalmology & Visual Science, 7:2832-2842

- Romero-Moya D, Santos-Ocana C, (...), Perdiguero E, (...), Munoz-Canoves P, Artuch R, Navas P & Menendez P 2017, 'Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q(10) Deficiency', Stem Cells, 7:1687-1703

- Perdiguero E, Serrano AL & Munoz-Canoves P  2017, 'Cilia Control Fat Deposition during Tissue Repair', Developmental Cell, 2:114-116

- Solanas G, Peixoto FO, Perdiguero E, Jardí M, Ruiz-Bonilla V, (...) Sassone-Corsi P, Muñoz-Cánoves P & Benitah SA 2017, ‘Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress.’ Cell. 170:678-692

Selected research activities

- Keystone Symposia on Inflammation and Fibrosis. USA.

- International Society of Stem Cell Research. Switzerland.

- Gordon Conference, Myogenesis. Italy.

- Gordon Conference, Biology of Aging. Switzerland.

- ConBio, Japan.