Antonio Postigo

Institut d'Investigacions Biomèdiques August Pi i Sunyer

Life & Medical Sciences


* ICREA Research Professor. IDIBAPS (Barcelona)

* Adjunct Visiting Professor, JG Brown Cancer Center (USA)


* Special Fellow & Research Instructor (Div Mol. Oncology, Washington Univ, USA)


* Public Agencies: European Commission, Ministry of Economy & Competitiveness (MINECO), AGAUR, 

* Private Foundations: Leukemia Research Foundation, AVON Breast Cancer Campaign, La Marató de TV3 Foundation, La Caixa Foundation,  Spanish Association Against Cancer (AECC), Olga Torres Foundation, Academy of Medical and Health Sciences of Catalonia & Balearic Islands

Research interests

The group investigates the molecular mechanisms regulating gene expression during cell differentiation and cancer. As molecular models, we use the ZEB family of transcription factors (ZEB1 and ZEB2) and their different cofactors. Research in the laboratory aims at understanding the expression and function of ZEB factors in stem cell determination, normal cell differentiation, malignant transformation and tumor initiation and progression. Our work involves high throughput techniques as well as in vivo transgenic mouse models and uses normal and malignant cells from multiple tissue systems, namely, epithelial, skeletal muscle and hematopoietic.

Selected publications

- Cortes M, Sanchez-Moral L, de Barrios O, Fernández-Aceñero MJ, Martínez-Campanario MC, Esteve-Codina A, Darling DS, Gyorffy B, Lawrence T, Dean DC & Postigo A* 2017, 'Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles', EMBO J., 36:3336-55. (* corresponding author)

- de Barrios O, Győrffy B, Fernández-Aceñero MJ, Sánchez-Tilló E, Sánchez-Moral L, Siles L, Esteve-Arenys A, Roué G, Casal JI, Darling DS, Castells A, Postigo A* 2017, 'ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1', Gut, 66:666-82. (* corresponding author). Note: Highlighted in a Commentary and selected for a video Abstract in the journal.

Selected research activities

1) Director of Ph.D. dissertations that were defended during 2017: 3

O de Barrios (Univ of Barcelona), awarded Feb 2017

M Cortes (Univ of Barcelona), awarded May 2017

L Siles (Univ of Barcelona), awarded June 2017

2) Grant Evaluations for international agencies during 2017

Medical Research Council (MRC),  United Kingdom

Institut National du Cancer (INCa), France

Czech Science Foundation (GACR), Czech Republic

3) Appointments to the Editorial Board of Scientific Journals

NEW appointments during 2017: 2 journals

Total ongoing editorial board memberships: 11 journals