Luis Serrano

Centre de Regulació Genòmica

Life & Medical Sciences

I did my PhD at the CBM in Madrid on the role of the carboxy-terminal region of tubulin on polymerization and MAP binding. Then I moved to the UK to work on protein folding. In 1993 I moved to the EMBL as a GL and started a new activity related to Protein design. After 6 years I was promoted to Senior Scientist. 2 years later I was appointed head of the Structural & Computational Biology programme. At that time we moved into the field of protein misfolding and amyloidoses diseases. We also started a new area of research on Systems Biology, designing small gene networks, doing computer simulations on them and performing experiments to test the predictions. After 14 years at the EMBL I moved to Spain to lead a programme working on Systems Biology. I was appointed vice-director before finally becoming the CRG director in July 2011. My group is focused on Synthetic Biology, engineering and designing of biological systems using our knowledge on protein design and gene networks.

Research interests

The group of Luis Serrano is interested in the quantitative understanding and in the rational design of Biological Systems. To achieve this goal they combine theoretical and experimental approaches and develop appropriate software. Of particular interest for the group is the combination of protein design and network analysis to understand signal transduction and gene regulation. As a more ambitious project the group is part of a consortium with the EMBL in Heidelberg aiming at obtaining for the first time a global quantitative understanding of a living system, Mycoplasma pneumonia.

Selected publications

- Trussart M, Yus E, Martinez S, Bau D, Tahara YO, Pengo T, Widjaja M, Kretschmer S, Swoger J, Djordjevic S, Turnbull L, Whitchurch C, Miyata M, Marti-Renom MA, Lluch-Senar M & Serrano L 2017, 'Defined chromosome structure in the genome-reduced bacterium Mycoplasma pneumoniae', Nature Communications, 8, 14665.

- Stojanovski K, Ferrar T, Benisty H, Uschner F, Delgado J, Jimenez J, Sole C, de Nadal E, Klipp E, Posas F, Serrano L & Kiel C 2017, 'Interaction Dynamics Determine Signaling and Output Pathway Responses', Cell Reports, 19, 1, 136 - 149.

- Kiel C, Lastrucci C, Luthert PJ & Serrano L 2017, 'Simple and complex retinal dystrophies are associated with profoundly different disease networks', Scientific Reports, 7, 41835.

- Yus E, Yang J-S, Sogues A & Serrano L 2017, 'A reporter system coupled with high-throughput sequencing unveils key bacterial transcription and translation determinants', Nature Communications, 8, 368.

Selected research activities

- Organizer:

Courses@CRG: Whole Cell Modeling, focused on multi-algorithm whole-cell modeling.

- Participation in international Congresses:

SBHD, Heidelberg: Is gene-/network- and pathway-centric (interactome) approach the best way to look at complex diseases?, Germany

International Symposium on Personalized Medicine, German Cancer Research Center (DKFZ): A network/system biology approach to reveal new insights in Age-related Macular Degeneration pathogenesis., Heidelberg, Germany

IRI Life Sciences seminar series: Is it possible to computer model a cell?, Germany

EPFL Seminar series, ”Is it possible to understand a simple biological system in a quantitative manner?, France