Gian Gaetano Tartaglia

Centre de Regulació Genòmica

Life & Medical Sciences

* 2014 - ICREA Research Professor * 2013 ERC Starting Grant * 2010 - Group Leader, Bioinformatics and Genomics Program, Centre for Genomic Regulation, Barcelona (Spain) * 2011 - Clare Hall Life Member, University of Cambridge (UK) * 2005-2010 - Postdoctoral Fellow, Clare Hall College, Chemistry Department, University of Cambridge (UK) * 2001-2005 - PhD, Biochemistry Department, University of Zurich, Zurich (CH) * 1996-2000 - MPhil Theoretical Physics, Statistical Mechanics, University la Sapienza, Rome (Italy)

Research interests

My main focus is to understand the role played by RNA molecules in protein networks. Characterizing protein-RNA associations is key to unravel the complexity and functionality of mammalian genomes and will open up therapeutic avenues for the treatment of a broad range of human disorders.  Using  computational and experimental approaches I study ribonucleoprotein complexes involved in i) transcriptional and translational regulation (e.g., X-chromosome inactivation) and ii) neurodegenerative diseases (examples include Parkinson’s SNCA and Amyotrophic Lateral Sclerosis proteins TDP-43 and FUS).  I aim to discover the involvement of RNA molecules in regulatory networks controlling protein production and I am interested in understanding mechanisms whose alteration lead to aberrant aggregation.  We have recently observed that interaction between proteins and mRNAs induce feedback loops that are crucial in protein homeostasis. We also found that specific proteins and RNAs phase separate in the cytosol and nucleus when their abundance is significantly high and we are investigating  how large assemblies formation affects cell function.

Selected publications

- Cirillo D, Blanco M, Armaos A, Buness A, Avner P, Guttman M, Cerase A & Tartaglia GG 2017, 'Quantitative predictions of protein interactions with long noncoding RNAs', Nat Methods, 1;14(1):5-6.     

- Gelpi E, Botta-Orfila T, Bodi L, Marti S, Kovacs G, Grau-Rivera O, Lozano M, Sánchez-Valle R, Muñoz E, Valldeoriola F, Pagonabarraga J, Tartaglia GG & Milà M 2017, ' Neuronal intranuclear (hyaline) inclusion disease and fragile X-associated tremor/ataxia syndrome: a morphological and molecular dilemma', Brain., 140(8):e51. 

- Marchese D, Botta-Orfila T, Cirillo D, Rodriguez JA, Livi CM, Fernández-Santiago R, Ezquerra M, Martí MJ, Bechara E & Tartaglia GG 2017, 'Discovering the 3' UTR-mediated regulation of alpha-synuclein', Nucleic Acids Research, (45), 22, 12888-12903.

- Armaos A, Cirillo D & Tartaglia GG 2017, 'omiXcore: a web server for prediction of protein interactions with large RNA', Bioinformatics, 33,(19):3104-3106. 

- Delli Ponti R, Marti S, Armaos A, Tartaglia GG 2017, 'A high-throughput approach to profile RNA structure', Nucleic Acids Research, 45(5): e35.

Selected research activities

- Proof of Concept Commercialization Gap Fund grant on the design of RNA aptamers;  

- The post-doc Benedetta Bolognesi became PI at IBEC;

- The doctoral student Davide Cirillo received the prize for best PhD thesis at UPF;

- Editor of two special issues of Frontiers in Molecular Sciences: "The non-coding RNA world" and "Disordered Systems: From Physics to Biology";

- In 2017 the articles and video clips mentioning my science reached an audience of 12 millions of people, resulting in an economic value of more than 64 thousand euros.