Patrick Aloy

Institut de Recerca Biomèdica de Barcelona

Life & Medical Sciences

Dr Patrick Aloy is an ICREA Research Professor and Principal Investigator of the Structural Systems Biology lab at the IRB. He has a BSc in Biochemistry and a MSc in Biotechnology from the Univ. Autònoma de Barcelona, Spain, and spent six years as postdoctoral researcher and staff scientist at the European Molecular Biology Laboratory, Heidelberg, Germany. For twenty years, Dr Aloy has been developing and implementing new technologies and algorithms, applying state-of-the-art methods to specific problems and bridging the gap between theoretical models and experiments in different disciplines. In the last years, he has pioneered system-scale analyses of macromolecular assemblies and networks using high-resolution three-dimensional structures, which has become a new discipline in structure prediction. Dr Aloy has over 100 publications in first-rate journals, with over 10,000 citations and remarkable press coverage, illustrating the scientific and social impact of the work.

Research interests

The main goal of my laboratory is to combine computational and structural biology with interaction discovery experiments to unveil the basic wiring architecture of physio-pathological pathways. It is our believe that a deeper knowledge of the global topology of interactome networks related to human disease will have important bearings in the discovery of new drug targets and biomarkers, optimisation of preclinical models and understanding how biological networks change from the healthy state to disease.

Selected publications

- Bertoni M & Aloy P 2018, 'DynBench3D, a Web-Resource to Dynamically Generate Benchmark Sets of Large Heteromeric Protein Complexes', Journal Of Molecular Biology, 430, 21, 4431 - 4438.

- Juan-Blanco T, Duran-Frigola M & Aloy P 2018, 'Rationalizing Drug Response in Cancer Cell Lines', Journal of Molecular Biology, 430:3016-3027

- Wuchty S, Mueller SA, Caufield JH, Haeuser R, Aloy P, Kalkhof S & Uetz P 2018, 'Proteome Data Improves Protein Function Prediction in the Interactome of Helicobacter pylori', Molecular & Cellular Proteomics, 17, 5, 961 - 973.

- Schlereth K, Weichenhan D, Bauer T, Heumann T, Giannakouri E, Lipka D, Jaeger S, Schlesner M, Aloy P, Eils R, Plass C & Augustin HG 2018, 'The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium', Elife, 7, e34423.

- Mateo L, Guitart-Pla O, Duran-Frigola M & Aloy P 2018, 'Exploring the OncoGenomic Landscape of cancer', Genome Medicine, 10, 61.

- Persi E, Duran-Frigola M, Damaghi M, Roush WR, Aloy P, Cleveland JL, Gillies RJ & Ruppin E 2018, 'Systems analysis of intracellular pH vulnerabilities for cancer therapy', Nature Communications, 9, 2997.

- Hennrich ML, Romanov N, Horn P, Jaeger S, Eckstein V, Steeples V, Ye F, Ding X, Poisa-Beiro L, Lai MC, Lang B, Boultwood J, Luft T, Zaugg JB, Pellagatti A, Bork P, Aloy P, Gavin A-C  & Ho AD  2018, 'Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline', Nature Communications, 9, 4004.