Eduardo Eyras

Universitat Pompeu Fabra

Life & Medical Sciences

E Eyras is ICREA Research Professor since January 2005. After graduating in Physics (U. of Granada, 1995) he did a PhD in Mathematics (U. of Groningen, The Netherlands, 1999) and postdoc (U. of Cambridge, UK)  (1999-2001). In 2001, Eyras joined the Sanger Institute, Cambridge, UK (2001-2004), where he worked on methods for alternative splicing prediction and participated in the analyses of the human, mouse and rat genomes. He has also contributed to the analyses of alternative splicing in the chicken and cow genome genomes and since 2007, he has been organizer of the RNA workshop of the ISMB conference. In 2008 he was awarded a Young Investigator Grant of the EURASNET network, and in 2013 he was a visiting professor at the U. of Toronto. E. Eyras leads a research group on Computational RNA Biology and Disease and teaches Machine Learning in genomics in the Masters of Bioinformatics for Health of the UPF.

Research interests

My group works on the development of computational tools to study mechanisms of RNA processing and its role in disease. We develop tools to identify RNA splicing signatures of therapeutic vulnerability in rare diseases and cancer, and develop new algorithms to facilitate the systematic implementation of long-read RNA sequencing in precision medicine.

Selected publications

- Singh B, Trincado JL, Tatlow PJ, Piccolo SR & Eyras E 2018, 'Genome Sequencing and RNA-Motif Analysis Reveal Novel Damaging Noncoding Mutations in Human Tumors', Molecular Cancer Research, 16, 7, 1112 - 1124.

- Trincado JL, Entizne JC, Hysenaj G , Singh B, Skalic M, Elliott DJ & Eyras E 2018, 'SUPPA2: fast, accurate, and uncertainty-aware differential splicing analysis across multiple conditions', Genome Biology, 19, 40.

- Jayasinghe RG, Cao S, Gao Q, Wendl MC, Vo NS, Reynolds SM, Zhao Y, Climente-Gonzalez H, Hector; Chai S, Shengjie; Wang F, Varghese R, Huang M, Liang W-W, Wyczalkowski MA, Sengupta S, Li Z, Payne SH, Fenyo D, Miner JH, Walter MJ, Vincent B, Eyras E, Chen K, Shmulevich I, Chen F & Ding L 2018, 'Systematic Analysis of Splice-Site-Creating Mutations in Cancer', Cell Reports, 23, 1, 270 

- Dotu I, Adamson SI, Coleman B, Fournier C, Ricart-Altimiras E, Eyras E & Chuang JH 2018, 'SARNAclust: Semi-automatic detection of RNA protein binding motifs from immunoprecipitation data', Plos Computational Biology, 14, 3, e1006078.

- Pagès A, Dotu I, Pallarès-Albanell J, Martí E, Guigó R & Eyras E 2018 'The discovery potential of RNA processing profiles', Nucleic Acids Res. 46(3):e15.

Selected research activities

  • Co-organizer of the RNA track of the ISMB (Intelligent Systems for Molecular Biology) 2018 in Chicago 2018
  • Co-organizer of the Conference Bermuda Principles – Impact on Splicing 2018 in Bermuda
  • Interviewed by the Bermuda Broadcasting Company
  • Keynote speaker at the 2nd Caparica Splicing Conference “Splicing 2018”. Portugal, 16-19 July 2018.
  • Invited speaker at the RNA Metabolism session of th Annual AACR conference, 14-18 April, 2018, Chicago.
  • Invited speaker at the New Scientific Approaches session of the 2018 European Congress of Endocrinology,  19-22 May  Barcelona.