Toni Gabaldón

Centre de Regulació Genòmica

Life & Medical Sciences

I'm a biochemist and molecular biologist by training (Universities of Valencia and Mainz). After several years working on a molecular biology lab, and attracted by the emerging fields of genomics and bioinformatics, in 2001 I moved to the comparative genomics group of Martijn Huynen in the NCMLS, The Netherlands. In 2005, I obtained a PhD in Medical Sciences (Radbout University Nijmegen), and then moved, thanks to an EMBO fellowship, to the bioinformatics department at CIPF (Valencia). In September 2008 I started my own group in the Bioinformatics and Genomics department at CRG. In 2013 I was awarded an ERC starting grant and an ICREA research professorship. In 2017 I was awarded the ERC consolidator Grant and the Margaret Dayhoff Award. I have always used an evolutionary perspective to address different biological questions. I am not only interested in understanding how complex biological systems work, but also how they have come to be as they are.

Research interests

My main research interest is to understand the complex relationships between genome sequences and phenotypes and how these two features evolve within and across species. I generally use large-scale phylogenetics and molecular evolution approaches that allow looking at the evolution of genomes from the perspective of all of their genes, and apply these analyses to a variety of biological questions related to the evolution and function of biological communities, organisms, organelles, pathways, and families of protein-coding and non-coding genes. I have a special interest in understanding processes related to human pathogenesis. Through collaborations with experimental groups, I apply comparative genomics to discover new mechanisms and genes involved in interesting processes, especially those of clinical relevance. Given our exposure to new types and scales of data, my group has had the need to develop novel bioinformatics tools to fill in existing gaps.

Selected publications

- Willis JR, Gonzalez-Torres P, Pittis AA, Bejarano LA, Cozzuto L, Andreu-Somavilla N, Alloza-Trabado M, Valentin A, Ksiezopolska E, Company C, Onywera H, Montfort M, Hermoso A, Iraola-Guzman S, Saus E, Labeeuw A, Carolis C, Hecht J, Ponomarenko J & Gabaldon T 2018, 'Citizen science charts two major "stomatotypes" in the oral microbiome of adolescents and reveals links with habits and drinking water composition', Microbiome, 6, 218.

- Kotlobay AA, Sarkisyan, et. al.. 2018, 'Genetically encodable bioluminescent system from fungi', Proceedings Of The National Academy Of Sciences Of The United States Of America, 115, 50, 12728 - 12732.

- Carreté L, Ksiezopolska E , Pegueroles C, Gómez-Molero E, Saus E, Iraola S, Loska D, Bader O. Fairhead C & Gabaldón T 2018, 'Patterns of genomic variation in the opportunistic pathogen Candida glabrata suggest the existence of mating and a secondary association with humans', Current Biology, 28, 1, 15

-  Mixão V & Gabaldón T 2018, 'Hybridization and emergence of virulence in opportunistic human yeast pathogens', Yeast, 35, 1, 5 - 20.

- Julca I, Marcet-Houben M, Vargas P & Gabaldon T 2018, 'Phylogenomics of the olive tree (Olea europaea) reveals the relative contribution of ancient allo- and autopolyploidization events', Bmc Biology, 16, 15.

- Saus E, Willis JR, Pryszcz LP, Hafez A, Llorens C, Himmelbauer H & Gabaldon T 2018, 'nextPARS: parallel probing of RNA structures in Illumina', Rna, 24, 4, 609 - 619.

- Ropars J et. al. 2018, 'Gene flow contributes to diversification of the major fungal pathogen Candida albicans', Nature Communications, 9, 2253.

- Gonzalez-Torres P & Gabaldon T 2018, 'Genome Variation in the Model Halophilic Bacterium Salinibacter ruber', Frontiers In Microbiology, 9, 1499.