Cayetano González

Institut de Recerca Biomèdica de Barcelona

Life & Medical Sciences

After completing a PhD on fly genetics in the laboratory of Pedro Ripoll at the Centre for Molecular Biology (CBM, Madrid, Spain), Cayetano González moved to David Glover's lab in the UK, first at Imperial College and later as a CRC Joint Principal Investigator at Dundee. In 1994, he took his first independent position, as a Group Leader at EMBL (Heidelberg, Germany). After the customary nine-year period at EMBL, he moved to the Centro Nacional de Investigaciones Oncológicas (CNIO, Madrid, Spain). In 2004 he moved to his present post at the Institute for Research in Biomedicine (IRB Barcelona) where he leads the Cell Division Group. In 2007 he was elected to full membership of the European Molecular Biology Organisation (EMBO).

Research interests

We model cancer in flies to understand the cellular and molecular changes that drive malignant growth. We focus on the mechanisms of malignant transformation in larval brains where we have found abnormal self-renewing asymmetric division often results in malignant growth. Some of our experimental tumor models  are driven by the ectopic expression of germline proteins. We are interested in the mechanisms that bring about genome instability in these tumors and try establishing the actual extent to which such lesions contribute to tumor progression. We develop and make extensive use of microscopy techniques. We demonstrated that the microtubule cytoskeleton of Drosophila neuroblasts is governed by the distinct behaviour displayed by centrosomes in these cells. We maintain an active line of research to identify new centrosomal proteins and found some with human orthologs that are linked to human pathologies.

Selected publications

– Rossi F, Attolini CS, Mosquera JL & Gonzalez C 2018, ‘Drosophila larval brain neoplasms present tumour-type dependent genome instability’, G3(Bethesda). Mar 28;8(4):1205-1214.

– Reina J, Gottardo M, Riparbelli MG, Llamazares S, Callaini G & Gonzalez C 2018, “Centrobin is essential for C-tubule assembly and flagellum development in Drosophila melanogaster spermatogenesis”, J Cell Biol, 217, 7, 2365 – 2372.

Selected research activities

Selected Invited Conferences and Meetings

June 2018: Barcelona BioMed Conference: Centrosomes, cilia and cell cycle in development and disease. Barcelona. Spain.

June 2018: Annual Meeting 2018: Portuguese Society of Genetics. i3S. Porto. Portugal.

September 2018: London Molecular Cancer Talk Series. London. UK.

September 2018: EMBO-Basel Life 2018: Molecules in Biology and Medicine (Session Chair). Basel. Switzerland.

October 2018: Workshop on Developmental Cell Biology of Drosophila. Ringberg Castle. Germany.

Selected Invited Seminars

March 2018: Invited Special Seminar, The Gurdon Institute. Cambridge. UK.

April 2018: IDIBELL. Barcelona. Spain.

Professional Services

HFSP fellowship review committee meeting 2018. Strasbourg. France.

Conference organization: 4th Spanish Conference on The Molecular, Cellular ad Developmental Biology of Drosophila. Begur. Spain.

2018-2021: Member of European Science Foundation (ESF) College of Expert Reviewers