Andreas Meyerhans

Universitat Pompeu Fabra

Life & Medical Sciences

University Education - 1987 PhD in Chemistry, University of Hamburg, Germany. - 1982 Diploma in Chemistry, University of Hamburg, Germany. Professional Positions - Since 2010 ICREA Research Professor at Pompeu Fabra University, Barcelona. - 1998-2009 Full Professor, Saarland University, Germany. - 1990-1998 Assistant Professor, University of Freiburg, Germany. - 1988-1990 Postdoctoral Fellow, Institute Pasteur, Paris, France. - 1987-1988 Postdoctoral Fellow, Institute Biotechnological Research, Braunschweig, Germany.

Research interests

Infections with non-cytopathic viruses usually have 2 different outcomes. They may be eliminated by host immune responses (acute infections) or they may persist lifelong (persistent infections). Medically important examples are the Hepatitis B virus (HBV), the Human Immunodeficiency virus (HIV) and the Hepatitis C virus (HCV) that in adults usually follow an acute (HBV), a persistent (HIV) or an either acute or persistent (HCV) infection course. My laboratory is interested (i) to understand the factors that regulate the decision between an acute versus a persistent infection course, (ii) to define the factors that control the dynamic balance of virus expansion and immune control in persistent infections, and (iii) to generate quantitative descriptions of the virus/immune system dynamics by mathematical modeling.

Selected publications

- Gonzalez-Cao M, Karachaliou N, Santarpia M, Viteri S, Meyerhans A & Rosell R 2018, 'Activation of viral defense signaling in cancer', Therapeutic Advances In Medical Oncology, 10.

- Sadiq SK, Mirambeau G & Meyerhans A 2018, 'Equilibrium Model of Drug-Modulated GagPol-Embedded HIV-1 Reverse Transcriptase Dimerization to Enhance Premature Protease Activation', Aids Research And Human Retroviruses, 34, 9, 804 - 807.

- Bocharov G, Meyerhans A, Bessonov N, Trofimchuk S & Volpert V 2018, 'Interplay between reaction and diffusion processes in governing the dynamics of virus infections', Journal Of Theoretical Biology, 457, 221 - 236.

- Bocharov G, Volpert V, Ludewig B & Meyerhans A 2018, Mathematical Immunology of Virus InfectionsSpringer International Publishing AG, part of Springer Nature.

- Kobayashi-Ishihara M, Terahara K, Martinez JP, Yamagishi M, Iwabuchi R, Brander C, Ato M, Watanabe T, Meyerhans A & Tsunetsugu-Yokota Y 2018, 'Antisense RNA by Itself Has Regulatory Function and May Curtail Virus Reactivation From Latency', Front Microbiol. 9:1066.

- Olvera A, Martinez JP, Casadella M, LlanoA, Rosas M, Mothe B, Ruiz-Riol M, Arsequell G, Noguera-Julian M, Paredes R, Meyerhans A & Brander C 2018, 'Benzyl-2-Acetamido-2-Deoxy-alpha-D-Galactopyranoside Increases Human Immunodeficiency Virus Replication and Viral Outgrowth Efficacy In Vitro', Frontiers In Immunology, 8, 2010.

- Argilaguet J, Pedragosa M, Esteve-Codina A, Riera G, Vidal E, Peligero-Cruz C, Andreu D, Kaisho T, Bocharov G, Ludewig B, Heath S & Meyerhans A 2018, 'Time-resolved systems analysis of virus infection fate regulation: the XCL1-XCR1 communication axis links T cell exhaustion with effector maintenance', European Journal Of Immunology, 48, 21 - 21.

Selected research activities

Co-editor for Frontiers in Immunology on a special issue on "Mathematical Modeling of the Immune System in Homeostasis, Infection and Disease"