Marco Milán

Institut de Recerca Biomèdica de Barcelona

Life & Medical Sciences

I graduated in Biology at the Universidad Complutense (Madrid, 1991) and obtained my PhD in the laboratory of Antonio García-Bellido at the Centro de Biología Molecular-Severo Ochoa (Madrid, 1995). A couple of years later, I joined the laboratory of Stephen M. Cohen at the EMBL in Heidelberg, where I got a position as Staff Scientist until 2003. In 2003, I got my present position as ICREA Research Professor at the Institute for Research in Biomedicine (IRB Barcelona) leading the Development and Growth Control Laboratory. Since 2007, I am also the Head of the Cell and Developmental Biology Programme at the IRB. In 2018, I was appointed Head of the Mechanisms of Disease Programme at the IRB. In 2007, I was elected EMBO Young Investigator. I was Visiting Professor at the National University of Singapore in 2010. I am currently a member of the editorial boards of EMBO Journal, and Disease, Models and Mechanisms. 

Research interests

Research in my lab is centered around the two following topics:

1. Cell and tissue biology of Chromosomal Instability (CIN): CIN, defined as an increased rate of changes in chromosome structure and number, is a feature of most, if not all, solid tumors. Our lab has recently developed an epithelial model of CIN in Drosophila where the relevant cell populations and pertinent cell interactions involved in the response of an epithelial tissue to CIN have been identified. We are currently characterizing at the genetic and molecular level CIN-induced cellular bahaviours such as epithelial to mesenchymal (EMT)-like cell fate transition, tissue invasiveness and senescence. 

2. Regulation of tissue size: We use the epithelial primordium of the Drosophila wing to address how the size and fate of a developing organ is regulated by the activity of morphogens and their gradients. 


Selected publications

- Muzzopappa M & Milan M 2018, 'Epithelial tumors: Growing from within', Fly, 12, 2, 127 - 132.

- Benhra N, Barrio L, Muzzopappa M & Milán M 2018, 'Chromosomal instability induces cellular invasion in epithelial tissues', Developmental Cell, 47, 2, 161.

Selected research activities

-  Co-organizer of the "5th Drosophila Growth and Regeneration Meeting" Girona (Spain), 2018.