Antonio Postigo

Institut d'Investigacions Biomèdiques August Pi i Sunyer

Life & Medical Sciences

CURRENT POSITION:

* ICREA Professor of Life and Medical Sciences. IDIBAPS (Barcelona)

* Adjunct Visiting Professor, JG Brown Cancer Center, Univ. of Louisville School of Medicine (USA)

IMMEDIATE PREVIOUS POSITION:

* Special Fellow & Instructor. Washington University School of Medicine (USA)

RESEARCH FUNDING:

* Public Agencies: European Commission / Ministry of Economy & Competitiveness (MINECO) / AGAUR,

* Private Foundations: Leukemia Research Foundation / AVON Breast Cancer Campaign / La Marató de TV3 Foundation / La Caixa Foundation / Spanish Association Against Cancer (AECC) / Olga Torres Foundation / Academy of Medical and Health Sciences of Catalonia / Duchenne Parent Project Association


Research interests

Our group studies molecular mechanisms regulating gene expression in health and disease with a particular focus on transcriptional regulation. Ongoing projects investigate gene regulation in inflammation, cancer, stem cell determination and differentiation, and tissue injury and regeneration. We use a wide range of technical approaches that include conditional transgenic mice, ex vivo culture and manipulation of normal and malignant primary cells, differentiation of human embryonic stem cells, and high-throughput techniques (e.g., RNAseq, proteomics). As molecular models, we use the EMT transcription factors ZEB1 and ZEB2 that play key roles in a number of physiological and pathological processes.

Selected publications

– Liu Y, Siles L, Lu X, Dean K, Cuatrecasas M, Postigo A* & Dean DC* 2018, ‘Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells‘, Nature Communications, 9:2424 (*co-corresponding authors). IF: 12.4. NOTE: Selected by the journal for “Editors’ Highlights”

– Ninfali C, Siles L, Darling DS & Postigo A* 2018, ‘Regulation of muscle atrophy-related genes by the opposing transcriptional activities of ZEB1/CtBP and FOXO3‘, Nucleic Acid Res, 46:10697-708​ (*corresponding author). IF: 11.6

– Invited REVIEW: Liu Y, Siles L, Postigo A* & Dean DC* 2018, ‘Epigenetically distinct sister chromatids and asymmetric generation of tumor-initiating cells’, Cell Cycle, 17:2221-9 (* co-corresponding authors).

Selected research activities

Grant Evaluations for international agencies during 2018:

* Fondo de Investigación Científica y Tecnológica (FonCyT), Argentina (Feb 2018)

* Institut National du Cancer (INCa), France (June 2018)

Membership in the Editorial Boards of Scientific Journals: 

* Total ongoing editorial board memberships: 11 journals