Ángel Raya

Centre de Medicina Regenerativa de Barcelona

Life & Medical Sciences

Ángel Raya is an ICREA Research Professor at the Center of Regenerative Medicine in Barcelona (CMRB). He obtained his MD in 1990 from the University of Valencia, Spain and a PhD degree from the same university in 1995 for studies carried out at the Department of Physiology and at the Department of Neurology, Mayo Clinic, Rochester, MN. He pursued postdoctoral training at the Instituto de Investigaciones Citológicas (currently, Centro de Investigación Príncipe Felipe) in Valencia, from 1995-2000. He then was a Research Associate (2000-2004) and a Senior Research Associate (2004-2006) in the Gene Expression Laboratory of the Salk Institute for Biological Studies, La Jolla, CA. He returned to Spain in 2006 and was the Scientific Coordinator at the CMRB until 2009, when he joined the Institute for Bioengineering of Catalonia (IBEC) as Group Leader of the Control of Stem Cell Potency group. In 2014 he was appointed Director at CMRB.

Research interests

Our research work aims to understand the tissue, cellular and molecular mechanisms that determine the regenerative response in certain species of vertebrates, as well as the genetic and epigenetic mechanisms that control cellular reprogramming. This phenomenon provides a link between the traditional study of epimorphic regeneration and the induced pluripotency strategies of regenerative medicine.

Selected publications

- Olgasi et al. 'Patient-Specific iPSC-Derived Endothelial Cells Provide Long-Term Phenotypic Correction of Hemophilia A', Stem Cell Reports, 11, 6, 1391 - 1406. 2018

- Notari et al. 'The local microenvironment limits the regenerative potential of the mouse neonatal heart'. Sci Adv,  Vol. 4, no. 5, eaao5553. 2018

- Parga et al. 'Prostaglandin EP2 Receptors Mediate Mesenchymal Stromal Cell-Neuroprotective Effects on Dopaminergic Neurons', Mol Neurobiol, 55 (6): 4763-4776. 2018

- Matamoros-Angles et al. 'iPS cell cultures from a Gerstmann-Sträussler-Scheinker patient with the Y218N PRNP mutation recapitulate Tau pathology'. Mol Neurobiol, 55:3033-48. 2018

- Kim et al, ‘The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity’, Mol Neurobiol, 55, 9, 7533–7552. 2018

- Fontcuberta-PiSunyer et al. ‘Modulation of the endocrine transcriptional program by targeting histone modifiers of the H3K27me3 mark’, Biochim Biophys Acta, 1861(5):473-480. 2018

- Tolosa et al. ‘MicroRNA alterations in iPSC-derived dopaminergic neurons from Parkinson disease patients’, Neurobiol Aging, 69:283-291. 2018

- Suh et al. 'Long-Term Labeling of Hippocampal Neural Stem Cells by a Lentiviral Vector', Frontiers In Molecular Neuroscience, 11, 415. 2018

Selected research activities

Patents filled

Valls-Margarit M, Iglesias O, Jane R, Martinez E, Raya A. Human cardiac tissue construct related methods of use, Ownership: CMRB/IBEC, Priority number: EP18382391, Priority Country: Europe, Priority date: 04/06/2018


Invited speaker

Ramon Areces International Symposium on Applications of Gene Editing, Madrid 01/18

9th SETGyC Biennial Congress, Mallorca 03/18

IBV/CSIC Seminar Series, Valencia 06/18

SSIEM Annual Symposium, Athens 09/18

2nd NMS Symposium, Lisbon 10/18