Luis Serrano

Centre de Regulació Genòmica

Life & Medical Sciences

I did my PhD at the CBM in Madrid on the role of the carboxy-terminal region of tubulin on polymerization and MAP binding. Then I moved to the UK to work on protein folding. In 1993 I moved to the EMBL as a GL and started a new activity related to Protein design. After 6 years I was promoted to Senior Scientist. 2 years later I was appointed head of the Structural & Computational Biology programme. At that time we moved into the field of protein misfolding and amyloidoses diseases. We also started a new area of research on Systems Biology, designing small gene networks, doing computer simulations on them and performing experiments to test the predictions. After 14 years at the EMBL I moved to Spain to lead a programme working on Systems Biology. I was appointed vice-director before finally becoming the CRG director in July 2011. My group is focused on Synthetic Biology, engineering and designing of biological systems using our knowledge on protein design and gene networks.

Research interests

The group of Luis Serrano is interested in the quantitative understanding and in the rational design of Biological Systems. To achieve this goal they combine theoretical and experimental approaches and develop appropriate software. Of particular interest for the group is the combination of protein design and network analysis to understand signal transduction and gene regulation. As a more ambitious project the group is part of a consortium with the EMBL in Heidelberg aiming at obtaining for the first time a global quantitative understanding of a living system, Mycoplasma pneumonia.

Selected publications

- Radusky L, Modenutti C, Delgado J, Bustamante JP, Vishnopolska S, Kiel C, Serrano L, Marti M & Turjanski A 2018, 'VarQ: A Tool for the Structural and Functional Analysis of Human Protein Variants', Frontiers In Genetics, 9, 620.

- Carleton LA, Chakravarthy R, van der Sloot AM, Mnich K, Serrano L, Samali A & Gorman AM 2018, 'Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity', Biochemical And Biophysical Research Communications, 495, 1, 700 - 705.

- Delgado Blanco J, Radusky L, Climente-Gonzalez H & Serrano L 2018, 'FoldX accurate structural protein-DNA binding prediction using PADA1 (Protein Assisted DNA Assembly 1)', Nucleic Acids Research, 46, 8, 3852 - 3863.

- Besray Unal E, Kiel C, Benisty H, Campbell A, Pickering K, Bluethgen N, Sansom OJ & Serrano L 2018, 'Systems level expression correlation of Ras GTPase regulators', Cell Communication And Signaling, 16, 46.

- Yang J-S, Garriga-Canut M, Link N, Carolis C, Broadbent K, Beltran-Sastre V, Serrano L & Maurer SP 2018, 'rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions', Nature Communications, 9, 3747.

- Zapata L, Pich O, Serrano L, Kondrashov FA, Ossowski S & Schaefer MH 2018, 'Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome', Genome Biol,19(1): 67.

- Dmitrijeva M, Ossowski S, Serrano L & Schaefer MH 2018, 'Tissue-specific DNA methylation loss during ageing and carcinogenesis is linked to chromosome structure, replication timing and cell division rates', Nucleic Acids Res, 46(14): 7022-7039.

Selected research activities

- The MycoSynVac Project coordinated by Luis Serrano was selected to be presented at the European parliament during the event:High-level conference EU research and innovation in our daily life -Panel 1: Health and wellbeing" on Nov. 27th, 2018: