Xavier Trepat

Institut de Bioenginyeria de Catalunya

Engineering Sciences

Xavier Trepat received a BSc in Physics in 2000 and a BSc in Engineering in 2001. In 2004 he obtained his PhD from the Medical School at the University of Barcelona. He then joined the Program in Molecular and Integrative Physiological Sciences at Harvard University as a postdoctoral researcher. In 2008 he became a "Ramón y Cajal" researcher at the University of Barcelona and in January 2011 an ICREA Research Professor at the Institute for Bioengineering of Catalonia (IBEC). He is Group Leader of the Integrative Cell and Tissue Dynamics research line at IBEC. In 2015 he won the Banc de Sabadell Award for Biomedical Research.

Research interests

We aim at understanding how physical forces and molecular control modules cooperate to drive biological function. We develop new technologies to map and perturb the main physical properties that determine how cells and tissues grow, move, invade and remodel. By combining this physical information with systematic molecular perturbations and computational models we explore the principles that govern the interplay between chemical and physical cues in living tissues. We study how these principles are regulated in physiology and development, and how they are derailed in cancer and aging.

Selected publications

- Elosegui-Artola A, Trepat X & Roca-Cusachs P 2018, 'Control of Mechanotransduction by Molecular Clutch Dynamics', Trends In Cell Biology, vol. 28, no. 5, 356 - 367.

- Latorre E, Kale S, Casares L, Gómez-González M, Uroz M, Valon L, Nair RV, Garreta E, Montserrat N, Del Campo A, Ladoux B, Arroyo M & Trepat X 2018, 'Active superelasticity in three-dimensional epithelia of controlled shape', Nature, 563(7730):203-208.

- Good M & Trepat X 2018, 'Cell parts to complex processes, from the bottom up', Nature, 563(7730):188-189. 

- Uroz M, Wistorf S, Serra-Picamal X, Conte V, Sales-Pardo M, Roca-Cusachs P, Guimerà R & Trepat X 2018, 'Regulation of cell cycle progression by cell–cell and cell–matrix forces', Nature Cell Biology, vol. 20, no. 6, pp 646-654.

- Labernadie A & Trepat X 2018, 'Sticking, steering, squeezing and shearing: cell movements driven by heterotypic mechanical forces', Current Opinion in Cell Biology, vol. 54, pp 57-65.

- Trepat X & Sahai E 2018, 'Mesoscale physical principles of collective cell organization', Nature Physics, 14, 7, 671 - 682.

- Shellard A, Szabo A, Trepat X & Mayor R 2018, 'Supracellular contraction at the rear of neural crest cell groups drives collective chemotaxis', Science, 362, 6412, 339 - +.

- Pardo-Pastor C, Rubio-Moscardo F, Vogel-González M, Serra SA, Afthinos A, Mrkonjic S, Destaing O, Abenza JF, Fernández-Fernández JM, Trepat X, Albiges-Rizo C, Konstantopoulos K, Valverde MA 2018, 'Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses', Proceedings of the National Academy of Sciences, vol. 115, no. 8, pp 1925-1930.