CURRENT POSITION:

* ICREA Professor of Life and Medical Sciences. IDIBAPS (Barcelona)

* Adjunct Visiting Professor, JG Brown Cancer Center, Univ. of Louisville School of Medicine (USA)

IMMEDIATE PREVIOUS POSITION:

* Special Fellow & Instructor. Washington University School of Medicine (USA)

RESEARCH FUNDING:

* Public Agencies: European Commission / Ministry of Science, Innovation and Universities / Catalan Agency for University and Research Grants (AGAUR)

* Private Foundations: Leukemia Research Foundation / Duchenne Parent Project Association / AVON Breast Cancer Campaign / Spanish Association Against Cancer (AECC) / La Marató de TV3 Foundation / Olga Torres Foundation / La Caixa Foundation / Catalan Academy of Medical and Health Sciences

Research interests

Our group studies molecular mechanisms regulating cell plasticity in health and disease with a particular focus on transcriptional regulation. Ongoing projects investigate gene regulation in inflammation, cancer initiation and progression, stem cell determination and differentiation, and tissue injury and regeneration. We use a wide range of technical approaches that include conditional transgenic mice, ex vivo culture and manipulation of normal and malignant primary cells, differentiation of human embryonic stem cells, and high-throughput techniques (e.g., RNAseq, proteomics). As molecular models, we use the EMT transcription factors ZEB1 and ZEB2 that play key roles in the regulation of cell plasticity.