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Manel Esteller

Manel Esteller

Institut de Recerca contra la Leucèmia Josep Carreras

Life & Medical Sciences

Manel Esteller (Sant Boi de Llobregat, Barcelona, Catalonia, Spain, 1968) graduated in Medicine with Honours from the Universitat de Barcelona in 1992, where he also obtained his PhD degree in molecular genetics in 1996. He was an Invited Researcher at the School of Biological and Medical Sciences at the University of St. Andrews (Scotland, UK). From 1997 to 2001, He was a researcher at the Johns Hopkins University and School of Medicine (Baltimore, USA) where he established promoter hypermethylation of tumour suppressor genes as a hallmark of all human tumours. From Oct. 2001 to Sept. 2008 he was CNIO Cancer Epigenetics Laboratory’s leader. Since Oct. 2008 untill May 2019, he was the Director of the Cancer Epigenetics and Biology Program (PEBC) at the Bellvitge biomedical campus. He is currently Director of the Josep Carreras Leukaemia Research Institute (IJC) and Chairman of Genetics in the School of Medicine of the UB.

Research interests

-Definition of the Epigenome and Epitranscriptome of Cancer Cells: Profile of DNA methylation and histone modifications in tumor suppressor genes and repetitive sequences in cancer. Global and gene-specific definition of aberrant epigenetic changes and functional consequences in transcription regulation, DNA repair and chromosome instability. -Study of the Epigenetics and Epitranscriptomics Machinery and Mechanisms: Role and function of DNA and RNA methyltransferases, specificity of methyl-CpG binding domain proteins (the nuclear factors that recognize DNA methylation), analysis of biological properties of histone deacetylases and methyltransferases (enzymes that modify histones). -Study of Mutations in the Epigenetic Machinery: The mechanisms underlying the disruption of the epigenetic landscape in transformed cells are unknown. -Study of the Epigenetic and Genetic Disruption of Non-Coding RNAs in Human Cancer. -Characterization of the Epitranscriptome in Human Diseases.

Selected publications

– Castro de Moura M, Davalos V, Planas-Serra L, Alvarez-Errico D, Arribas C, [….], Llucià-Carol L, Planas AM, Pérez-Tur J, Fernandez-Cadenas I, Villares P, Tenorio J, Colobran R, Martin-Nalda A, Soler-Palacin P, Vidal F, Pujol A, Esteller M 2021, ‘Epigenome-wide association study of COVID-19 severity with respiratory failure’, Ebiomedicine, 66, 103339.

– Coll-SanMartin L, Davalos V, Piñeyro D, Rosselló-Tortella M, [….], Kohno T, Esteller M 2021, ‘Gene Amplification-Associated Overexpression of the Selenoprotein tRNA Enzyme TRIT1 Confers Sensitivity to Arsenic Trioxide in Small-Cell Lung Cancer’, Cancers, 13, 8, 1869.

– Esteve-Puig R, Climent F, Piñeyro D, Domingo-Domènech E, Davalos V, Encuentra M, […], Rechavi G, Sureda A, Esteller M 2021, ‘Epigenetic Loss of m1A RNA Demethylase ALKBH3 in Hodgkin Lymphoma Targets Collagen Conferring Poor Clinical Outcome‘, Blood, 137, 7, 994 – 999.

– Wheeler DA, Takebe N, Hinoue T, Hoadley KA, Cardenas MF, Hamilton AM, Laird PW, Wang L, Johnson A, Dewal N, Miller V, Piñeyro D, Castro de Moura M, Esteller M, Shen H,  [….], Conley BA, S. Ivy P, Staudt LM, 2021, ‘Molecular Features of Cancers Exhibiting Exceptional Responses to Treatment’Cancer Cell, 39, 1, 38-53.e7.

Selected research activities

Elected Member of the Academia European

Elected Fellow of the European Academy of Sciences

Elected as Section Editor for Epigenetics at “Molecular Oncology”

Award Dr. Fernández-Cruz Memorial Foundation

Award E-nnova Health in Big Data and Artificial Intelligence

Top 0.001% World Scientist by Stanford University

Highly Cited Researcher™2021 by Clarivate Web of Science

ICREA Memoir 2021