Eduardo Eyras

Eduardo Eyras

Institut Hospital del Mar d'Investigacions Mèdiques

Life & Medical Sciences

E Eyras is ICREA Research Professor since January 2005. After graduating in Physics (U. of Granada, 1995) he did a PhD in Mathematics (U. of Groningen, The Netherlands, 1999) and postdoc (U. of Cambridge, UK)  (1999-2001). In 2001, Eyras joined the Sanger Institute, Cambridge, UK (2001-2004), where he worked on methods for alternative splicing prediction and participated in the analyses of the human, mouse and rat genomes. He has also contributed to the analyses of alternative splicing in the chicken and cow genome genomes and since 2007, he has been organizer of the RNA workshop of the ISMB conference. In 2008 he was awarded a Young Investigator Grant of the EURASNET network, and in 2013 he was a visiting professor at the U. of Toronto. E. Eyras leads a research group on Computational RNA Biology and Disease and teaches Machine Learning in genomics in the Masters of Bioinformatics for Health of the UPF.

Research interests

My group works on the development of computational tools to study mechanisms of RNA processing and its role in disease. We develop tools to identify RNA splicing signatures of therapeutic vulnerability in rare diseases and cancer, and develop new algorithms to facilitate the systematic implementation of long-read RNA sequencing in precision medicine.

Selected publications

– Bueno C, Velasco-Hernandez T, Gutierrez-Aguera F, Zanetti SR, Baroni ML, Sanchez-Martinez D, Molina O, Closa A, Agraz-Doblas A, Marin P, Eyras E, Varela I &  Menendez P 2019, ‘CD133-directed CAR T-cells for MLL leukemia: on-target, off-tumor myeloablative toxicity’, Leukemia, 33, 8, 2090 – 2093.