Paolo Melchiorre

Paolo Melchiorre

Institut Català d'Investigació Química

Experimental Sciences & Mathematics

Paolo Melchiorre is an ICREA Research Professor at the Institute of Chemical Research of Catalonia (ICIQ) in Tarragona. Paolo studied Chemistry at the University of Bologna (Italy) where he graduated in 1999. He began his doctoral studies in Chemistry working in the area of enantioselective catalysis. Before obtaining his PhD in 2003, he spent a research period in Denmark working with Prof. Karl Anker Jørgensen, Århus University, where his studies centered on asymmetric organocatalysis. Afterwards, he worked as a postdoctoral associate at the Industrial Chemistry Faculty of the Bologna University. There, he began his independent studies on the development of novel organocatalytic asymmetric transformations. In October 2007, he took a permanent position as an Assistant Professor at Bologna University. In September 2009, Paolo moved to Catalonia as ICREA Research Professor and ICIQ Senior Group Leader.

Research interests

My main interest is on the discovery and mechanistic elucidation of new enantioselective organocatalytic and photochemical processes that address unsolved problems in synthetic methodology. My research on light-driven stereocontrolled processes aims at increasing process efficiency using a mechanistically-guided approach, controlling reaction selectivity, and reducing the environmental impact of chemical synthesis. My approach is based on the combination of two powerful fields of molecule activation, visible light photocatalysis and metal-free organocatalysis, to develop fundamentally new and ground-breaking strategies to asymmetric catalysis via the intermediacy of light-mediated open-shell redox processes and excited-state reactivity patterns. The motivation is that the use of light excitation to bring a molecule from its ground state to an electronically excited state can unlock previously inaccessible reaction pathways, thereby creating new synthetic opportunities.

Selected publications

– van Leeuwen T, Buzzetti L, Perego LA & Melchiorre P 2019, ‘A Redox-Active Nickel Complex that Acts as an Electron Mediator in Photochemical Giese Reactions’, Angewandte Chemie-international Edition, 58, 15, 4953 – 4957.

– Cuadros S, Horwitz MA, Schweitzer-Chaput B & Melchiorre P 2019, ‘A visible-light mediated three-component radical process using dithiocarbamate anion catalysis’, Chemical Science, 10, 21, 5484 – 5488.

– Gandolfo E, Tang X, Roy SR & Melchiorre P 2019, ‘Photochemical Asymmetric Nickel-Catalyzed Acyl Cross-Coupling’, Angewandte Chemie-international Edition, .

– Bieszczad B, Perego LA & Melchiorre P 2019, ‘Photochemical C-H Hydroxyalkylation of Quinolines and Isoquinolines’, Angewandte Chemie-international Edition, 58, 47, 16878 – 16883.

– Goti G, Bieszczad B, Vega-Penaloza A & Melchiorre P 2019, ‘Stereocontrolled Synthesis of 1,4-Dicarbonyl Compounds by Photochemical Organocatalytic Acyl Radical Addition to Enals’, Angewandte Chemie-international Edition, 58, 4, 1213 – 1217.

– Schweitzer-Chaput B, Horwitz MA, de Pedro Beato E & Melchiorre P 2019, ‘Photochemical generation of radicals from alkyl electrophiles using a nucleophilic organic catalyst’, Nature Chemistry, 11, 2, 129 – 135.

– Buzzetti L, Crisenza GEM & Melchiorre P 2019, ‘Mechanistic Studies in Photocatalysis’, Angewandte Chemie-international Edition, 58, 12, 3730 – 3747.

Selected research activities

* January 2019, PM becomes an Associate Editor of Chemical Science (RSC)

* “Giorgio Modena” medal from Italian Chemical Society

* PM has delivered lectures at 12 International congresses (e.g. European Symposium of Organic Chemistry, ESOC, Vienna; Bürgenstock Conference, Brunnen) and 15 scientific talks at universities and chemical industries.