Pura Muñoz-Cánoves

Pura Muñoz-Cánoves

Universitat Pompeu Fabra

Life & Medical Sciences

Pura Muñoz-Cánoves studied Pharmacology in the University of Valencia. She obtained her PhD in 1990 in the Autonomous University of Madrid for work carried out at The Scripps Research Institute (La Jolla, USA). She did postdoctoral work at the University of California-San Diego and The Scripps Research Institute, and in 1994 she joined the Cancer Research Institute in Barcelona as a postdoc, becoming an independent group leader in 1997. In 2002 her group moved to the Center for Genomic Regulation (CRG) in Barcelona, and she became a senior scientist in 2007 in that Institution. Late 2008 she moved to the Pompeu Fabra University (UPF) after becoming an ICREA Research Professor. Through the UPF, she holds a collaborative agreement with the Spanish National Center on Cardiovascular Research. Her research focuses on deciphering the mechanisms regulating skeletal muscle regeneration and growth, in physiology and disease.

Research interests

Our main objective is to understand the mechanisms regulating stem cell homeostasis and regenerative functions: how stem cells maintain quiescence, are activated, transit to proliferative expansion and differentiation, and finally self-renew, and how they interact with the external inflammatory environment. Research is specially focused on stem cells of skeletal muscle. Recent studies from the laboratory have shed light on 1) age-associated muscle decline and wasting (sarcopenia) and loss of stem-cell regenerative functions with aging; and 2) the physiopathology of muscular dystrophies, with a specific interest in the contribution of inflammation and fibrosis to dystrophy progression. These findings are relevant for regenerative medicine.

Selected publications

– Perdiguero E, Moiseeva V, Muñoz-Cánoves P 2019, ‘Simultaneous Isolation of Stem and Niche Cells of Skeletal Muscle: Applicability for Aging Studies‘, Methods Mol Biol. 2045:13-23

Selected research activities

Conferences, Invited Speaker:

  • International Symposium of ”Living in Space”. Japan Aerospace Exploration Agency (JAXA). Kyoto, Japan. March 2019 (invited by Dr. Atsuko Sehara)
  • Riken Institute. Kobe, Japan. March 2019 (invited by Dr. Fumio Matsuzaki)
  • Osaka University. Osaka, Japan. March 2019 (invited by Dr. So-ichiro Fukada)
  • International Conference on Aging Biology. Beijing, China. April 2019 (invited by Dr. Guanghui Liu)
  • Gordon Research Seminar Conference on Myogenesis. Il Ciocco, Italy.  June 2019 (invited by Dr. Benedicte Chazaud)
  • Marabou’s Foundation. Meeting on Nutrition and Stem Cell Integrity in Ageing. Stockholm, Sweden. June 2019 (invited by Dr. Bo Angelin)
  • International Society of Stem Cell Research (ISSCR). Los Angeles, USA. June 2019 (invited by Dr. Douglas Melton)
  • *Keynote Lecture: EMBO Conference. 10th International Fission Yeast Meeting. Barcelona, Spain. July 2019 (invited by Dr. Jose Ayté)
  • FEBS Workshop Aging and Regeneration. Innsbruck, Austria. September 2019 (invited by Dr. Pidder Jansen)
  • *Keynote Lecture: Frontiers Conference on “Skeletal muscle: development, regeneration and disease”. American Association of Cell Biology. Costa Rica. September 2019 (invited by Drs. Alessandra Sacco, Peter Zammit and Fabio Rossi)
  • 3RD International stem cell meeting. Crete, Greece. October 2019 (invited by Drs. Kursad Turksen and Jeff Dilworth)
  • Des Treilles Foundation Conference on Stem cells and stress response mechanisms. Les Arcs-Draguignan, France. October 2019 (invited by Dr. Emmanuelle Passegué)