Pura Muñoz-Cánoves

Pura Muñoz-Cánoves

Universitat Pompeu Fabra

Life & Medical Sciences

Pura Muñoz-Cánoves studied Pharmacology in the University of Valencia and obtained her PhD in 1990 in the Autonomous University of Madrid for work carried out at The Scripps Research Institute (La Jolla, USA). She did postdoctoral work at the University of California-San Diego and The Scripps Research Institute, and in 1994 joined the Cancer Research Institute in Barcelona as a postdoc, becoming an independent group leader in 1997. In 2002 she moved to the Center for Genomic Regulation (CRG) in Barcelona where became a senior scientist in 2007. Late 2008 she moved to the Pompeu Fabra University (UPF) after becoming an ICREA Research Professor. Through the UPF, she holds a collaborative agreement with the Spanish National Center on Cardiovascular Research. She is Member of EMBO and the Academia Europaea. Her research focuses on deciphering the mechanisms regulating skeletal muscle regeneration and growth, in physiology and disease.

Research interests

Our main objective is to understand the mechanisms regulating stem cell homeostasis and regenerative functions: how stem cells maintain quiescence, are activated, transit to proliferative expansion and differentiation, and finally self-renew, and how they interact with the external inflammatory environment. Research is specially focused on stem cells of skeletal muscle. Recent studies from the laboratory have shed light on 1) age-associated muscle decline and wasting (sarcopenia) and loss of stem-cell regenerative functions with aging; and 2) the physiopathology of muscular dystrophies, with a specific interest in the contribution of inflammation and fibrosis to dystrophy progression. These findings are relevant for regenerative medicine.

Selected publications

- Garcia-Prat L, Perdiguero E, Alonso-MartiN S, Dell'Orso S, Ravichandran S, Brooks SR, Juan AH, Campanario S, Jiang K, Hong X, Ortet L, Ruiz-Bonilla V, Flandez M,  Moiseeva V, Rebollo E, Jardi M, Sun HW, Musaro A, Sandri M, Sol A del, Sartorelli V, Munoz-Canoves P; 2020, 'FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age', Nature Cell Biology, 22, 11, 1307

- Segalés J, Perdiguero E, Serrano AL, Sousa-Victor P, Ortet L, Jardi M,  Budanov AV, Garcia-Prat L, Sandri M, Thomson DM, Karin M,  Hee Lee J, Muñoz-Cánoves P; 2020, 'Sestrin prevents atrophy of disuse and aging muscles by integrating anabolic and catabolic signals', Nature Communications, 11, 1, 189.

- Iavarone F, Guardiola O, Scagliola A, Andolfi G, Esposito F, Serrano A, Perdiguero E, Brunelli S, Munoz-Canoves P, Minchiotti G; 2020, 'Cripto shapes macrophage plasticity and restricts EndMT in injured and diseased skeletal muscle', EMBO Reports, 21, 4, e49075.

Selected research activities


- President of Fundamental Myology Commission of Association Française de Myopathies (AFM), Paris, France

- Member of the Editorial Board of the following Journals: Cell Stem Cell, Stem Cell Biology and Regenerative Medicine (Springer, Nature)

- Member of “Consejo Consultivo en Investigación, Desarrollo e Innovación de la Presidencia de la Generalitat Valenciana”

Conferences, Invited Speaker:

- Keystone Symposia on Intra- and Intercellular Mechanisms of Aging. Canada. February 2020 (invited by Drs. Johan Auwerx and Heinrich Jasper)

- Gordon Conference on Autophagy. Ventura, USA. March 2020 (invited by Dr Malene Hansen)

- Cold Spring Harbor Laboratory Conference on Mechanisms of Aging. September 2020 (invited by Drs. Shin-Ichiro Imai, Scott Pletcher and Meng Wang)

- EMBO Conference on Muscle Regeneration, Development and Disease.  France. October 2020 (invited by Drs. Drs. Fred Relaix and Krzysztof Jagla)