Patents 2019

30

Applications filed
ICREA         Patents

EXPERIMENTAL SCIENCES & MATHEMATICS

Xavier Barril
(UB)
  • Inhibitors of ERK nuclear translocation
Arjan Kleij
(ICIQ)
  • Sustainable process for preparing polyesters having high glass transition temperature
  • Sustainable process for preparing poly (limonene) Dicarbonate having high glass transition temperature
Victor Puntes
(ICN2 & VHIR)
  • BI-Functionalized nanoparticles, process for its preparation and uses therof
ENGINEERING SCIENCES
Jordi Arbiol
(ICN2)
  • Method to photo-capture CO2 with perovskite oxide compounds
Andreu Cabot
(IREC)
&
Joan Rosell
(URV)
  • Device and method for determining the speed of printing of a fiber and the length of a printed fiber
  • Printing device and method
José Antonio Garrido
(ICN2)
  • Amorphous highly porous reduced graphene oxide film and its applications
Miguel Ángel González Ballester
(UPF)
  • A computer implemented method, a system and computer programs for computing simultaneous rectilinear paths using medical
Daniel Maspoch
(ICN2)
&
Victor Puntes
(ICN2 & VHIR)
  • Water purification method
Josep Nogués
(ICN2)
  • Material que absorbe radiación electromagnética de longitudes de onda entre 300nm i 18 micras y aplicaciones
Valerio Pruneri
(ICFO)
  • Undisclosed titles (5)
Joan Rosell
(URV)
  • Device and method for determining the speed of printing of a fiber and the length of a printed fiber
Neus Sabaté Vizcarra
((IMB – CNM) – CSIC))
  • Procedimiento de cuantificación de la concentración de analitos en una celda electroquímica
Clivia Sotomayor
(ICN2)
  • A microstructured film comprising inorganic-organic hybrid polymers, a method for manufacturing thereof and a method for cooling the surface of an element by applying said microstructured film
Albert Tarancón
(IREC)
  • Electrochemical cell device for use in a SOFC and/or a SOEC and methods for operating a SOFC or a SOEC by using thereof
Sergio Valenzuela
(ICN2)
  • Displacement sensor
Niek van Hulst
(ICFO)
  • Common-path interferometric scattering imaging system and a method of using common-path interferometric scattering imaging to detect an object: U.S. Continuation-in-Part Patent
LIFE & MEDICAL SCIENCES
Eduard Batlle
(IRB Barcelona)
  • Predictive biomarkers for treatment of a cancer patient with TGF-beta signaling pathway inhibitors
  • TGFβ Inhibitor and Prodrugs
Miguel Chillón
(UAB & VHIR)
  • Vectors expressing klotho for treating cancer
Javier Martínez Picado
(IRSICaixa)
  • Microbicide compositions comprising Siglec-1 monoclonal antibodies for HIV-1 prevention and treatment
  • Siglec-1 monoclonal antibodies for treating and preventing HIV-1 and Ebola virus infections
Pablo Menéndez
(IJC)
  • CAR T-cells for CD1-positive cancer
Laura Soucek
(VHIO)
  • Combination therapy for the treatment of cancer
  • Methods for the diagnosis of lung cancer

Science to Society – ERC Proof of Concept grants

5

new grants in 2019

Jens Biegert | miniX - MINIaturitzed coherent soft X-ray source for research and industry

miniX – MINIaturitzed coherent soft X-ray source for research and industry

X-rays are a prime analytical tool across a diverse range of areas in our modern economy—from fundamental physics and chemistry research, to the pharmaceutical and semiconductor industries. In particular, sources of ultrafast coherent x-rays are expected to have a transformative impact in all of these areas due to their capacity to enable the study of interactions between charge carriers and atoms in gases, liquids and solids, in real-time, and with element specificity. Ease of use, compactness and price will prove vital for any new X-ray technology looking to find use in industrial applications. “miniX” will address all of these issues with the miniaturization of a laser-based soft x-ray source, designed for lay user operation and at low cost.


Jens BiegertInstitut de Ciències Fotòniques (ICFO)
ERC – PoC2018

Daniel Maspoch | Hybead - Hybrid Bead Adsorbents

HybeadHybrid Bead Adsorbents

Each year, millions of people, most of them children, die from diseases associated with inadequate water supply, sanitation and hygiene. In particular, exposure to heavy metals in drinking water, even at trace levels, poses a considerable health risk. As included in one of the seventeen sustainable development goals of the United Nations, “safe water and adequate sanitation are indispensable for healthy ecosystems, reducing poverty, and achieving inclusive growth, social well-being and sustainable livelihoods”. In this PoC project, named Hybrid Bead Adsorbents (Hybead), we aim to evaluate the feasibility of advancing Hybrid Inorganic Nanoparticle/Metal-Organic Frameworks Bead-type adsorbents into the pre-commercial stage, with the aim of accelerating their access to the market as an efficient technology for removing heavy metal ions from water. The first part of Hybead encompasses scaling-up of our current spray-drying synthesis of these beads from the gram-scale to economically viable kilogram-scale production. We will also shape the composite beads for proving its use into existing water purification technologies. This will entail shaping Hybead into granules and integrating them as fillers into polymer matrices to produce membranes by common industrial-scale methods (e.g. compaction and solvent casting). The second part of Hybead will be dedicated to intellectual property (IP) and market aspects needed for the pre-commercialization of this new technology for water purification. This study will include a patentability study, a freedom-to-operate (FTO) analysis and a market study to identify the filter producers that could ultimately serve as manufacturing partners. In this project we will endeavor to assess the commercial viability of with Hybead adsorbents, accelerate their market entry and ultimately, explore the possibility of launching a spin-off to manufacture and commercialize viable products.


Daniel MaspochInstitut Català de Nanociència i Nanotecnologia (ICN2)
ERC – PoC2019

Neus Sabaté | POWER-PATCH - Self-Powered Skin Patch for Cystic Fibrosis Diagnosis

POWER-PATCH – Self-Powered Skin Patch for Cystic Fibrosis Diagnosis
 
Cystic fibrosis (CF) is a genetic autosomal recessive disease, which induces mutations on a conductance transmembrane regulator protein (CFTR) that controls the exocrine system responsible or producing saliva, sweat, tears and mucus. The protein malfunction affects severely the lungs and digestive system. Patients with CF present also higher chloride contents in sweat than healthy subjects, so chloride testing in sweat has become the gold standard test for CF confirmation after new-born screening blood tests. However, tests on new-borns are not 100% sensitive and not universally stablished along European territory, which leads to patients with a late diagnostic that decreases their life quality and expectancy. The ‘sweat test’ requires either sophisticated analytical procedures or costly commercial analyzers and consumables that restrict the availability of the test to few specialized units scattered along the European territory. POWER-PATCH aims to evolve and promote the value of a novel, market disruptive patch that enables an affordable and easy-to-use sweat test for the screening of cystic fibrosis. The patch has been conceived to be applied on the forearm of the patient and yield a “positive” result in case of an abnormal conductivity level of sweat is detected. It combines the low cost and easy handling of paper that is associated with the filter paper-based diagnosis technique and at the same time allows obtaining a digital response with no further handling or treatment of the sample. Moreover, as it already contains a “battery sensor”, sweat collection and testing does not require additional equipment and can be easily taken to any clinical environment. Within this ERC PoC project, we aim to achieve (i) Technical validation and Clinical testing in a specialized CF unit and (ii) a business proposition in the form of a Business Plan containing strategies for commercialization, fundraising, IP management and future product development.

Neus SabatéInstitute of Microelectronics of Barcelona – Centre Nacional de Microelectónica (CSIC – IMB-CNM)
ERC – PoC2019

Jordi Sort | MAGIC-SWITCH: Magnetic Switch Controlled with Voltage

MAGIC-SWITCH Magnetic Switch Controlled with Voltage
 
We are living in a world that is increasingly driven by data. Governments, healthcare facilities, commercial businesses and individuals are all storing information in electronic form. This has led to the emergence of digital and cloud-based technologies. The ability to use information more efficiently has resulted in a rapid increase of the value of information. However, with the Big Data revolution, information is facing new challenges. Energy efficiency during writing of magnetic information needs to be improved. Thus, enhancing robustness in data storage systems is one of the major challenges in our modern society. Our vision for the near future is to turn the scientific output of the ERC Consolidator SPIN-PORICS into a new type of storage memory. MAGIC-SWITCH will deliver the prototype and business case for a new type of compact storage memory, at an industrial-relevant scale. The specific goal of this PoC project is to take the initial steps towards this vision by building a prototype (moving from Technology Readiness Level TRL 3 to 5), standardizing its manufacturing process and creating a business case for its commercial exploitation (including a pitch that can be used to close new partnerships or in fund-raising).

Jordi Sort – Universitat Autònoma de Barcelona (UAB)
ERC – PoC2019

Paul Verschure | cRGS - Cognitive Rehabilitation Gamming System (cRGS): a novel Virtual Reality-based system for the conjunctive training of stroke-derived cognitive impairments

cRGS – Cognitive Rehabilitation Gamming System (cRGS): a novel Virtual Reality-based system for the conjunctive training of stroke-derived cognitive impairments
 
The cDAC ERC Advanced project develops and validates a theory of consciousness and its application to the understanding and alleviation of its deficits. cDAC proposes that consciousness is a virtualization memory system that monitors and optimizes the real-time control of perception, cognition and action realized in a multi-layered architecture. Building on cDAC, we have advanced and validated new concepts and methods for the diagnostics and treatment of cognitive and affective deficits post-stroke. The current PoC project will now propel these interventions into the real-world by integrating them with the Rehabilitation Gaming System (RGS), creating cRGS. cRGS will be built by the integration of several paradigms and principles underlying perception, cognition, and emotion advanced in the cDAC theory of mind. cRGS will be developed to tackle unsolved problems in diagnosis, treatment, and prevention of cognitive impairments after stroke, dementia and depression that. affect more than 400 million people worldwide creating a severe health-related burden adding up to annual costs that are measured in trillions of euros, with depression being the leading cause of disability worldwide. cRGS taps into the latest technologies such as AI, VR, big data and cloud computing to provide treatment that does not require the presence of a health professional by building on the cDAC architecture for autonomous control. cRGS solves two significant obstacles in providing healthcare namely, the lack of resources and the lack of trained professionals. Concretely, this Proof of Concept will consist of the integration of the treatment paradigms created in cDAC to treat and diagnose aphasia, cognitive impairment, and depression in one platform. This prototype will be tested in terms of usability and adherence as well as its practical use at healthcare centers and at home.

Paul Verschure – Institut  de Bioenginyeria de Catalunya (IBEC)
ERC – PoC2018

11

active grants in 2019

Eduard Batlle | CRC-MTOs - Colorectal Cancer Mouse Tumor Organoids as Pre-clinical Models for Therapeautical Testing

CRC-MTOsColorectal Cancer Mouse Tumor Organoids as Pre-clinical Models for Therapeautical Testing

Colorectal cancer (CRC) is one of the leading causes of death by cancer, which is closely connected to the spread of the disease in the body. Among the most promising therapeutic strategies to treat late stage cancers are immunotherapies. But only 5% of such advanced patients respond to immunotherapies. Progress to understand to what extent patients with metastatic CRC may benefit from immunotherapy has so far been limited by the lack of preclinical model systems to study late stage CRC under fully immunocompetent conditions.

This project aims to generate a unique pre-clinical model of advanced colorectal cancer (CRC) based on mouse tumour organoids (MTOs) to use for therapeutic testing of oncology products. Prof. Batlle’s newly generated MTOs will provide unique tools ready to be licenced and exploited in strategic public-private collaborations, with the ultimate goal to aid in the development of new drugs to treat advanced CRC sufferers. The research that his team, based at IRB Barcelona, will develop under the ERC’s PoC scheme will leverage the know-how he obtained during his previous ERC Advanced Grant:  this involved the use of genome editing tools to modify organoids. This is Prof. Batlle’s second PoC grant, the first was to develop a test to predict the risk of CRC relapse.


Eduard BatlleInstitut de Recerca Biomèdica (IRB Barcelona)
ERC-PoC2018

José Ramón Galán-Mascarós | MEMCARB - Separation membranes for carbon dioxide removal from gas streams

MEMCARB – Separation membranes for carbon dioxide removal from gas streams

Carbon dioxide separation, capture and utilization is expected to become a major business opportunity in the near future. Beyond current industrial needs for natural gas or biogas purification, regulatory issues imposing emission control will also contribute to a fast growth in this market. At the industrial level, CO2 separation is still an expensive process, typically based in alkaline amine solutions or cryogenic distillation, and low-cost alternatives are needed. Membrane-based technologies are the most preferred for gas purification processes due to their easy implementation and very low operational costs. However, CO2 separation through membrane systems is not competitive nowadays, due to the low selectivity and poor stability of the available materials. This weakness precludes fully exploitation of the intrinsic benefits (functional and economic) of membrane technologies. We have discovered a porous metal organic framework (MOF) able to separate CO2 from a gas stream (including methane, nitrogen, oxygen, hydrogen, olefins, etc.) that confers organic polymer membranes unique separation capabilities. Composite membranes containing this MOF exhibit unique CO2/CH4 selectivities, at least one order of magnitude higher when compared with current state-of-the-art models. This opens unique possibilities to develop an efficient, robust and affordable membrane system for CO2 separation. Our MEMCARB technology, based on inexpensive starting materials, and obtained via industrially scalable processes, could have excellent market penetration for multiple applications (from gas purification of methane feeds, to treatment of exhaust gas). Through this project we will design, build and validate a membrane-based module for gas purification. The results will be analyzed and compared to current CO2 separation processes to further assess its viability and to identify its competitive advantages. If results are positive, a business plan and road to market will be established.


José Ramón Galán-MascarósInstitut de Català d’Investigació Química (ICIQ)
ERC – PoC2017

Gerasimos Konstantatos | SPECTRODOT - Hand-held broadband hybrid graphene-quantum dots spectrometer

SPECTRODOTHand-held broadband hybrid graphene-quantum dots spectrometer

Optical Spectrometry is a powerful non-destructive, high throughput technique used extensively for threat and hazardous substance detection, food inspection, process and environmental monitoring and quality control amongst others. The market is fragmented into many niche markets, mainly due to the different wavelengths ranges of interest. Hybrid graphene-quantum dot photodetectors can enable versatile spectrometer covering the whole spectral range from UV to mid-IR. The main goal of SPECTRODOT is to develop a prototype low-cost, hand-held spectrometer with broadband range from 400 to 2500 nanometres.


Gerasimos KonstantatosInstitut de Ciències Fotòniques (ICFO)
ERC – PoC2018

Frank Koppens | GTRACK - Hybrid quantum dot and graphene wearable sensor for eye tracking

GTRACK – Hybrid quantum dot and graphene wearable sensor for eye tracking

The main goal of GTRACK is to demonstrate a semi-transparent eye-tracking system that is disposed in the line of sight of the user, for portable applications. To this end, we will use hybrid Quantum Dot – Graphene photodetectors. Eye-tracking existed since the 1800’s, but is expected to appear abundantly in our daily lives with the advent of virtual and augmented reality. In the existing systems, the camera has to be placed sufficiently close to the eye to capture enough IR light at sufficiently high resolution, while not blocking the user’s vision. By placing the camera directly on the lens, all these disadvantages are circumvented. Moreover, larger detectors can increase the sensitivity of the detectors and hence decrease the power consumption of the active illumination, which would allow for portable applications.


Frank KoppensInstitut de Ciències Fotòniques (ICFO)
ERC – PoC2017

Pablo Menéndez | IT4B-ALL - Therapeutic immunotherapy targeting NG2 and CD22 antigens for MLL-rearranged and MLL-germline B-cell Acute Lymphoblastic Leukemia

IT4B-ALL – Therapeutic immunotherapy targeting NG2 and CD22 antigens for MLL-rearranged and MLL-germline B-cell Acute Lymphoblastic Leukemia

B-ALL is the commonest cancer of childhood. There remain childhood B-ALL subgroups with dismal prognosis such as infant B-ALL and B-ALL carrying MLL rearrangements (MLLr). In addition, the prognosis of adult B-ALL is worse, and refractory/relapse (R/R) B-ALL remains dismal. CD19-targeted immunotherapies have emerged as promising therapeutic approaches for R/R B-ALL. CD19 CAR T-cells have shown impressive efficacy in R/R B-ALL. However, relatively rapid relapses are frequently observed, a proportion of them losing CD19 expression upon CAR19 T-cell therapy due to massive antigen pressure over CD19, resulting in a myeloid lineage switch in MLLr B-ALL, or the selection of CD19-/CD34+ preleukemic progenitors. Further CD19-targeted therapy is thus ineffectual for CD19neg R/R B-ALL. Our overarching goal is to provide novel therapeutic options for (R/R) B-ALL.Targeting surface antigens whose expression, opposite to CD19, are commonly retained at relapse is a valid strategy to circumvent the loss of CD19 found in (R/R) B-ALL after CD19-targeted therapies. Recent work funded by my ERC-2014-CoG has identified NG2 and CD22 as key antigens to be targeted in (R/R) B-ALL. First, both antigens are retained in CD19neg R/R B-ALL. Second, NG2 is solely expressed in MLLr B-ALL, and is associated with CNS infiltration, aggressiveness and glucocorticoid resistance. Third, CD22 is a pan-B marker expressed developmentally earlier than CD19, and CD34+CD22+CD19- cells may represent pre-malignant progenitors escaping the CD19-targeted pressure. These results have just been protected by a European Patent (EPI173825514), and are the proof-of-principle demonstration of NG2 & CD22 representing promising immunotherapeutic targets, when combined with CD19 for both MLLr & MLL-germline B-ALL, respectively. Here we propose to consolidate preclinical work and GMP production of anti-NG2 monoclonal antibody and NG2/CD19 and CD22/CD19 CAR T-cells to launch a PhaseI academic clinical trial for R/R B-ALL.


Pablo MenéndezInstitut Josep Carreras (IJC)
ERC – PoC2018

Ángel R. Nebreda | p38_InTh - Innovative therapeutic tools to ameliorate chemotherapy-induced cardiotoxicity

p38_InTh – Innovative therapeutic tools to ameliorate chemotherapy-induced cardiotoxicity

p38_InTh aims at improving the potency of a new class of highly specific p38 pathway inhibitors and validate their potential therapeutic use to ameliorate chemotherapy-induced cardiotoxicity without affecting the cancer cell toxicity of the chemotherapeutic. Chemotherapeutics used for cancer treatments have serious side effects, both the most broad-spectrum ones (such as anthracyclines) and the directed ones (such as trastuzumab). In particular, the cardiotoxicity is a major issue associated to chemotherapy. Cardiooncology research has recently emerged to tackle this serious unmet medical need. The cardiotoxicity induced by chemotherapeutics includes from arrhythmia to heart failure. To mitigate it, cardiooncologists usually adjust the treatment with reduced doses for a longer period, but this makes the anticancer treatments less efficient and consequently reduces the quality of life of the patients. There is evidence that cardiomyocyte death induced by anthracyclines involves activation of a specific p38 pathway, suggesting that inhibition of this pathway may reduce the cardiotoxicity associated with chemotherapeutics. Over the last two decades, many p38 pathway inhibitors have been developed by industry. However, these are mostly ATP competitors and have shown disappointing results in clinical trials. In contrast, we have recently identified novel compounds that inhibit only one of the target isoforms and through a novel MoA, selectively antagonizing the activation of this isoform by one of its protein partners. We propose to improve the potency of these hits and validate their potential therapeutic use to ameliorate chemotherapy-induced cardiotoxicity without affecting the cancer cell toxicity. Importantly, our new drug would inhibit only a subset of the p38 pathway regulated functions, which is expected to result in increased specificity, thereby overcoming the undesired side-effects found in clinical trials for the classical ATP competitive p38 pathway inhibitors.


Ángel R. NebredaInstitut de Recerca Biomèdica (IRB Barcelona)
ERC – PoC2018

Samuel Sánchez Ordóñez | LABPATCH - Lab-in-a-patch for PKU self-assessment

LABPATCH – Lab-in-a-patch for PKU self-assessment

Phenilketonuria (PKU) is a congenital metabolic disease related to high levels of phenylalanine (Phe) in blood that, if not treated, can lead to intellectual disability, behavioural problems, and mental disorders. Life-long monitoring of Phe levels are necessary for PKU patients to avoid health (mainly neurological) issues. Currently available techniques for Phe assessment are costly, slow and take place only in clinical chemistry laboratories inside tertiary care hospitals, with a total analysis rate of one test every 1 month. Therefore, new technologies for frequent and rapid Phe analysis are required to improve PKU therapeutic efficacy, health monitoring and hence the quality of life of the patients. Here, we propose a fully integrated wearable patch for non-invasive self-assessment of PKU. The patch is designed to comfortably detect sweat Phe levels at home settings without medical expertise or expensive facilities. The patch contains electrodes modified with Phe-selective bioreceptors and is connected to a miniaturized controlling unit for electrode operation and wireless data transmission to external devices (smartphone, tablet, etc.). Overall, this project will provide, in an unprecedented manner, the fast monitoring of a rare disease with an integrated, compact, user friendly and non-invasive device. We aim at improving the way patients and doctors interact regarding the daily assessment of PKU. The produced devices will change how this rare disease is monitored, understood and will open new correlations between PKU and degree of health of patients. Furthermore, we expect that the concept of Lab-in-a-patch device proposed in this project will pave the way to the monitoring and assessment of other specific diseases.


Samuel Sánchez OrdóñezInstitut de Bioenginyeria de Catalunya (IBEC)
ERC – PoC2017

Luis Serrano | MycroVAP - Bacterial chassis for treating ventilator-asociated pneumonia (VAP)

MycroVAPBacterial chassis for treating ventilator-asociated pneumonia (VAP)

Among 65-80% of human infections are associated to biofilms, especially in respiratory infections or those associated with catheters. Endotracheal tube (ETT) biofilm is related to the development of ventilator-associated pneumonia (VAP), which occurs in 9–27% of all intubated patients. Those ETT-biofilms are mainly formed by Pseudomonas aeruginosa and/or Staphylococcus aureus, forming a protective barrier against antibiotics and the host immune system. The consequence of VAP is chronic inflammation resulting in slow but continuous decrease of lung function, which is the primary cause of mortality of patients at hospital wards, and is also associated with increased hospital morbidity; duration of hospitalization and consequently health care costs. Engineering bacteria to deliver locally therapeutic agents or to present antigens for vaccination is an emerging area of research with great clinical potential. Up to date, an attenuated BCG strain, used for prostate cancer vaccination, is the only example of a living bacteria used for human therapy. However, there are several studies worldwide at preclinical stage addressing the use of engineered bacteria for human therapy. We suggest here to test a non-pathogenic chassis of the mild human lung pathogen Mycoplasma pneumoniae, engineered to dissolve biofilms of S. aureus and P. aeruginosa for the treatment of VAP. The specific objectives of this proposal are: First, to confirm the safety of our bacterial chassis in the lung of animal models (mice and pigs). Second, to test the capacity of our engineered chassis to eliminate bacterial biofilms formed in endotracheal tubes and in mice models of biofilm formation. Success in both objectives will open the way to test our chassis in pig models of VAP as a first step towards its application in humans.

 


Luis Serrano – Centre de Regulació Genòmica (CRG)
ERC – PoC2018

Laura Soucek | SYST-iMYC - Development of an effective and safe systemic Myc inhibitor for the treatment of multiple cancer types

SYST-iMYCDevelopment of an effective and safe systemic Myc inhibitor for the treatment of multiple cancer types

Current cancer therapies target redundant cellular functions often compensated for by cancer cells, resulting in resistance to treatment. Here we propose an innovative approach to inhibit Myc, a non-redundant and “most-wanted” therapeutic target for human cancer. Targeting Myc has long been considered unfeasible because of the potentially catastrophic side effects in normal tissues. Against this dogma, we showed that Myc inhibition by Omomyc, a Myc mutant designed by Dr. Soucek, has a dramatic therapeutic impact in multiple mouse models of cancer, while causing only limited and reversible side effects. Critically, there is no emergence of resistance. Thanks to the ERC-2013-CoG n° 617473, we discovered the unexpected cell-penetrating properties of the purified Omomyc polypeptide. Moreover, we found that it is anti-tumorigenic after local (intranasal) delivery to mouse models of lung and brain tumors, and could therefore become the first clinically-viable direct Myc inhibitor. With this ERC PoC, we propose to develop a new drug based on an Omomyc variant that enables systemic treatment of several cancer types including lymphoma, breast, and melanoma. In all these cancers Myc contributes to multiple aspects of tumorigenesis including immune suppression. At the end of this project we will have a patent protected therapeutic polypeptide active in vitro and in vivo and ready to enter clinical trials Phase I/II in patients and to continue its commercialization. The forecasted peak revenue for such first-in-class drug in those indications reaches 2.612 M€ annually. With this ERC PoC project we will achieve essential milestones to develop this innovative therapeutic polypeptide by establishing the feasibility, including a commercial data package and cost estimations for the industrial production. Passing these milestones will de-risk the product and increase its value and probability of reaching the market by making it ready to be transferred to a spin-off company.


Laura SoucekVall d’Hebrón Institut d’Oncologia (VHIO)
ERC – PoC2018

Juan Valcárcel | VALSL - Valorisation of splice-switching oligonucleotides for lung cancer therapy

VALSL – Valorisation of splice-switching oligonucleotides for lung cancer therapy

Here we propose to test the therapeutic potential of a novel class of reagents, known as splicing-modifying antisense oligonucleotides, in preclinical models of lung adenocarcinoma, including patient-derived tumours in mice. Alternative splicing is a major mechanism of gene regulation by which different messenger RNAs and proteins are generated from a single gene, often displaying distinct, even antagonistic functions. Alterations in alternative splicing have been linked with a plethora of pathologies ranging from neurodegenerative disease to cancer. As a result of detailed mechanistic analyses of alternative splicing regulation in the context of the ERC-funded MASCP project, we have identified antisense oligonucleotides that modulate alternative splicing of a gene that plays key roles in the control of lung cancer cell proliferation. These reagents repress cell growth in vitro as well as inhibit tumour growth when administered intranasally in mouse models of lung adenocarcinoma. The main experimental goal of the ERC PoC proposal is to test the therapeutic value of the antisense oligonucleotides in a variety of patient-derived xenografts in mice, alone or in combination with other treatments, including chemotherapy. This will require previous optimization of dose and delivery route, which is being carried out with available support from other healthcare innovation funds. These goals are aligned with requests from various stakeholders, and funding from the ERC PoC program will be critical for successful valorisation of our assets, intellectual property protection and recruitment of venture capital to establish a spin-off company. Given the high incidence, poor prognosis and lack of efficient therapies for lung cancer, the work proposed can translate fundamental knowledge on molecular mechanisms of gene regulation derived from the ERC-funded MASCP project into applications whose valorisation can bridge the gap to market and provide added value for society.


Juan ValcárcelCentre de Regulació Genòmica (CRG)
ERC – PoC2017

Niek van Hulst | IBIS - Platform for label-free quantitative detection of single proteins and extracellular vesicles

IBIS – Platform for label-free quantitative detection of single proteins and extracellular vesicles

The main objective of the IBIS project is to develop an ultrasensitive, compact and low cost platform for the label-free quantitative detection of single proteins, and specifically the characterisation of nanometric extracellular vesicles. We will develop a prototype to transfer our novel detection scheme from the laboratory to the clinical environment and, based on user-feedback, develop a commercialization plan. In the fight against cancer and neurodegenerative diseases, exosomes are being perceived as potential biomarkers that can be sampled non-invasively. Reliable quantitative detection and analysis is needed to exploit the full potential of exosomes in diagnostics and therapy. The proposed innovation comprises a novel all optical approach: In-line Balanced Interference Scattering (IBIS). The balanced detection is implemented by a tailor-made attenuation mask into the back-focal-plane of a microscope, allowing the detection of particles as small as 15 kDa. The IBIS signal is directly proportional to the particle volume and can hence be used to quantify size distributions of nanoparticles reliably. IBIS microscopy only requires low-cost consumer grade detectors and an extremely simple optical setup. Specific goals of this proposed PoC project are: (i) Simplification of the current laboratory implementation to improve robustness and further reduce the cost, (ii) Careful characterisation of extracellular vesicle signals and binding behaviour under laboratory conditions, (iii) Construction of a compact benchtop prototype and implementation under clinical conditions, (iv) Feedback guided optimisation of the prototype by comparing laboratory (high sensitivity, specialist) and clinical (reduced sensitivity, non-specialist) results, (v) Design-optimisation of commercial implementations based on market research from clinical settings and national healthcare buyers. Definition of IP and market positioning and strategy.


Niek van HulstCentre de Ciències Fotòniques (ICFO)
ERC – PoC2016

Spin-off companies

3

Spin-off company created in 2019

MiWendo Solutions SL

MiWendo Solutions

Supported by UPF and ICREA
Entrepreneur: ICREA Research Professor Miguel Angel González Ballester
Born in September 2019

 

 

MiWEndo Solutions develops MiWEndo, a novel medical device that applies microwave imaging technology to colonoscopy. MiWEndo aims to contribute to improving prevention and diagnosis of colorectal cancer, as well as serving as an exploratory tool to increase the scientific knowledge about this type of cancer. MiWEndo automatises the detection of  polyps and raises an alarm when one is detected. Furthermore, it augments the field of view to 360º and provides quantitative tissue classification, without any modification to current clinical procedures.

Colon cancer is a highly prevalent and devastating disease. The current push for screening programs worldwide has led to an increase in colonoscopy procedures. Detection of polyps in these explorations highly relies on the experience of the clinical expert, and is therefore subject to subjectivity and fatigue. MiWEndo aims at providing a novel valuable tool to the clinician, thus contributing to reduce the number of missed polyps in colonoscopies.

The global market for colonoscopy is approximately 1550M€, with a yearly increase of 5%. The main target markets for MiWEndo, at present, are Europe, USA and Japan. MiWEndo is a patented device, and it is safe, complementary to existing colonoscopes and low-cost. MiWEndo will lead to increased polyp detection rates and better decision support, by providing more information about the malignancy of the tissue. It will also reduce time and cost, in terms of faster explorations, less repeated colonoscopies, reduced patient preparation time and earlier detection and treatment of colorectal cancer.

MiWEndo Solutions is a spin-off of Universitat Pompeu Fabra, Universitat Politècnica de Catalunya, Hospital Clínic de Barcelona and ICREA.

Further information:

[1] González Ballester et al. (2017), European patent no. EP3195786A1.

[2] Guardiola et al. (2018), Medical Physics, vol. 45(8), 3768-3782.

[3] Guardiola et al. (2019), IEEE Transactions on Antennas and Propagation, vol. 67(8), 4968-4977.

Ona Therapeutics SL

Supported by IRB Barcelona and ICREA
Entrepreneur: ICREA Research Professor Salvador Aznar Benitah
Born in May 2019

Ona Therapeutics is a biotech company, spin-off of ICREA and IRB, specialized in the discovery and development of therapeutic biologics targeting tumor metastatic-initiating cells and lipid metabolism. It was co-funded in February 2019 by ICREA researcher Salvador Aznar Benitah and Valerie Vanhooren (CEO). It is currently based at the Parc Cientific de Barcelona (PCB) and IRB Barcelona. ONA Therapeutics has been launched through an investment by Asabys Partners, who is a venture capital firm from Barcelona investing across the board in human healthcare, specialising in health-tech and biopharma industries.

Pentabilities SL

Supported by IPEG and ICREA
Entrepreneur: ICREA Research Professor Caterina Calsamiglia
Born in May 2019

 

Pentabilities offers a novel method to capture, track, and develop socioemotional skills. Pentabilities acknowledges your inner drivers, identifies key skills for you that are not measured in traditional learning practices, then defines an promotes these skills using evidence based assessment. Pentabilities is a spinoff of the ERC starting grant COMPSCHOICE 638893.