Elena Bosch (Barcelona, 1972) graduated in Biology at the Universitat de Barcelona in 1995 and, after pursuing her doctoral research on population genomics of the North African populations, obtained her PhD at the Universitat Pompeu Fabra. In February 2000, she moved to the UK, where she was appointed Research Assistant at the University of Leicester to work on the human Y chromosome diversity and dynamics, in the laboratory of Dr. Mark Jobling. In 2004, thanks to a “Ramón y Cajal” contract, she established her own research group on Evolutionary Population Genetics at the Universitat Pompeu Fabra. In December 2008, she was awarded tenure with an Associate Professor (“professor agregat”) position that changed to Assistant Professor (“professor titular”) in February 2012. In 2013, she was awarded with the Prize for Outstanding Teaching by the Social Council of the UPF. From June 2017 she is Deputy Director of the Institute of Evolutionary Biology, IBE (CSIC-UPF).

Research interests

My research group focuses on investigating different aspects of human genetic diversity. In particular, we are interested in adaptive traits that have undergone positive selection during human evolution and in the architecture of the genetic predisposition to complex disease. The search for genetic signatures of selection is pursued at different levels using comparative data and exploring intraspecific diversity patterns mainly within human populations but also in chimpanzees. Once these signals have been identified, we then aim to elucidate the genetic variants and molecular phenotypes underlying the genetic basis of adaptations by using in silico functional predictions and relevant molecular biology techniques. As for complex disease, we believe that the application of population genetic models can help in unraveling the genetic contribution to them as well as in understanding the differences in penetrance, age of onset, and risk allele frequencies between genetic disorders.

Keywords

Population genetics, evolution, human adaptation, evolutionary medicine and genetic epidemiology.