Marquès Bonet, Tomàs – ICREA Memoir 2021

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Tomàs Marquès-Bonet

Centre de Regulació Genòmica & Universitat Pompeu Fabra

Life & Medical Sciences

Dr. Marquès-Bonet is the Principal Investigator of the group "Comparative Genomics" and director of the Institute of Evolutionary Biology (IBE; UPF/CSIC) and at the CRG-CNAG. He started his own lab in 2010 with an ERC Starting Grant and was selected as ICREA in 2011. In 2013 he was selected for the EMBO young Investigator award. Starting on 2017 he is an HHMI International young investigator. His group aims to characterize human specific genomics features, including the combination of evolution and conservation genetics. With a total of more than 160 peer-reviewed publications, he has published as a senior authorship in Science (2016,2020), Nature (2013;2019), Genome Research (2015,2021), Plos Genetics (2013,2015) among others. He was director of the Institute of Evolutionary Biology (UPF-CSIC), 2017-2020. He was awarded with an ERC Consolidator 2019.

Research interests

What makes us human? This is a fundamental question in many disciplines. Our team analyzes a wide range of genome variants to determine processes, variants and molecular features that are intrinsic to our species. To do so, we study full genome, epigenomes and transcriptomic sequences of humans and great apes for a better understanding of human specific features.

Selected publications

– Liu, Shanlin; et al. (inlcuding Tomas Marques-Bonet) 2021, ‘Ancient and modem genomes unravel the evolutionary history of the rhinoceros family’, Cell, 184, 19, 4874 – +.

– Lukas FK Kuderna, Joseph Orkin, Tomas Marques-Bonet 2021, “The Diversity of Primates: From Biomedicine to Conservation Genomics”Annual Review of Animal Biosciences, 9, 103 – 124.

– Orkin, Joseph D.; Montague, Michael J.; Tejada-Martinez, Daniela; de Manuel, Marc; del Campo, Javier; Hernandez, Saul Cheves; Di Fiore, Anthony; Fontsere, Claudia; Hodgson, Jason A.; Janiak, Mareike C.; Kuderna, Lukas F. K.; Lizano, Esther; Martin, Maria Pia; Niimura, Yoshihito; Perry, George H.; Valverde, Carmen Soto; Tang, Jia; Warren, Wesley C.; de Magalhaes, Joao Pedro; Kawamura, Shoji; Marques-Bonet, Tomas; Krawetz, Roman; Melin, Amanda D. 2021, ‘The genomics of ecological flexibility, large brains, and long lives in capuchin monkeys revealed with fecalFACS’, Proceedings Of The National Academy Of Sciences Of The United States Of America, 118, 7, e2010632118.

– Rhie, Arang; et al. (inlcuding Tomas Marques-Bonet). 2021, ‘Towards complete and error-free genome assemblies of all vertebrate species’, Nature, 592, 7856, 737 – +.

– Serres-Armero, Aitor; Davis, Brian W.; Povolotskaya, Inna S.; Morcillo-Suarez, Carlos; Plassais, Jocelyn; Juan, David; Ostrander, Elaine A.; Marques-Bonet, Tomas 2021, ‘Copy number variation underlies complex phenotypes in domestic dog breeds and other canids’, Genome Research, 31, 5, 762 – 774.

– Garcia-Perez, Raquel; Esteller-Cucala, Paula; Mas, Gloria; Lobon, Irene; Di Carlo, Valerio; Riera, Meritxell; Kuhlwilm, Martin; Navarro, Arcadi; Blancher, Antoine; Di Croce, Luciano; Luis Gomez-Skarmeta, Jose; Juan, David; Marques-Bonet, Tomas 2021, ‘Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures’, Nature Communications, 12, 1, 3116.