Christian Brander obtained a PhD in Immunology at the University of Bern and completed his post-doctoral training at Harvard Medical School, focusing on T cell immunity to HIV. He led several international efforts to build HIV research capacities across Southern Africa and Central and South America. He joined ICREA in 2008 with an appointment at the IrsiCaixa Research Institute and as the scientific director of the Catalan HIV vaccine program HIVACAT. He is a co-inventor of the "HTI" immunogen, co-founder of AELIX Therapeutics and curator of the Los Alamos HIV Database. He serves on the SAB of the South African Brilliant Consortium and the IDORI Research Institute as well as the EDCTP-funded GREAT Consortium. He holds an appointment as Associate Professor at the University of Vic.
Research interests
Our group aims to understand the cellular immunity to viral infections in different disease contexts. Using complementary tools for immune analysis and integrated -omics approaches, we seek to identify functional correlates of effective antiviral immunity and to explore the underlying cellular and molecular mechanisms that mediate such virus control. We combine immune assays with epigenetics, communicome and transcriptomics analyses to assess to what degree and at which stages of different viral infections the effector function profiles of virus-specific T cells are epigenetically controlled. We are especially interested in understanding these mechanisms in lympho-proliverative and neurological diseases driven by these viral infections and pay special attention to TCR repertoires of the involved T cells and their antigen specificities.
Selected publications
- Bailón, L et al. 2025, 'Safety, immunogenicity and effect on viral rebound of HTI vaccines combined with a TLR7 agonist in early-treated HIV-1 infection: a randomized, placebo-controlled phase 2a trial', Nature communications, 16 - 1 - 2146.
- Bailón L, Brander C... et al. 2025, 'Predictors of virological outcomes after analytical interruption of antiretroviral therapy and HTI vaccination in early treated people with HIV-1._', Communications medicine, 6 - 1 - 11.
- Ruiz-Casas C, Brander C et al. 2025, 'Long-term neurocognitive outcomes of SARS-CoV-2 infection in a hamster model', Frontiers in microbiology, 16 - 1646616.
- Borgognone A, Brander C et al. 2025, 'Interactions between gut microbiota, plasma metabolome and brain function in the setting of a HIV cure trial', Frontiers in cellular and infection microbiology, 15 -1629901.
- Gunst JD et al 2025 'Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy: an individual data-based meta-analysis of 24 prospective studies', Nature Communications 16(1):906.
- Hartigan-O’Connor DJ & Brander C Chapter 6: Immunology. Mechanisms of CD4 decline. Fundamental of HIV Medicine 2025. Carolyn Chu (editor in chief), The American Academy of HIV Medicine.
- Bailón L, Martinez-Picado J & DUALITY Study Group et al. 2025, 'Impact of Dolutegravir Plus Lamivudine as First-line Antiretroviral Treatment on the Human Immunodeficiency Virus Type 1 Reservoir and Inflammatory Markers in Peripheral Blood', J Infect Dis. 231 - 3 - 600-610.
- Tatoud R, Lévy Y, Le Grand R, Alcami J, Barbareschi G, Brander C, et al. 2025, 'In danger: HIV vaccine research and development in Europe', PLOS Glob Public Health, 5 - 4 - e0004364.
- Bailón L et al 2025, 'Strategies to Minimize Time From HIV Acquisition to ART Initiation: The Barcelona Early-cART Program', Open Forum Infectious Diseases 12(9):ofaf545.