Paul Christou

Paul Christou

Universitat de Lleida

Life & Medical Sciences

BS Chemistry & PhD Plant Biochemistry, University College London. Senior Scientist at Agracetus Inc., Madison, WI, USA, where he developed genetic transformation technology that lead his group to generate the first commercial crop sold by Monsanto (Roundup Ready Soybean). Subsequently Head of Molecular Biotechnology Unit, John Innes Centre, Norwich, UK-led the Tropical Maize and Rice Biotechnology Laboratory sponsored by the Rockefeller Foundation. Head Crop Genetics & Biotechnology, Fraunhofer Institute Molecular Biotechnology & Applied Ecology, Aachen, Germany. Universitat de Lleida as an ICREA Professor & Head of the Applied Plant Biotechnology Laboratory. Founding Director Agrotecnio CERCA Center, 2013-2015. Recipient of ERC Advanced Grant BIOFORCE and ERC PoC Grant Multinutrient Maize. Received 2 Bill & Melinda Gate's grants. PI in 14 EU projects over past 25 years 2 as coordinator and 2 as deputy coordinator. Recipient of Narcís Monturioll Medal 2020.

Research interests

Our programs rely on our unique multi-gene/multi-pathway engineering capabilities to generate plants with high value recombinant pharmaceuticals for human health and veterinary medicine; cereals with enhanced nutrition, and novel strategies of sustainable agriculture with emphasis on developing countries, poverty alleviation and food security. A major focus is plant synthetic biology and genome editing. Our group is involved in training and capacity building in plant biotechnology focusing on developing countries. We also develop tools, methodology and a comprehensive understanding of the essential mechanisms underpinning the creation and performance of genome edited plants for the application of synthetic biology to major crops. During 2021 a major focus has been the use of plants to combat SARS-CoV-2.

Selected publications

- Muñoz-Basagoitia J, Monteirob FLL, et al. 2023, 'Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2', Proc Natl Acad Sci USA, 120 (10), e2214561120.

- Saba-Mayoral A, Rosa C, Sobrino-Mengual G, Armario-Najera V, Christou P & Capell T 2023. 'Production of the SARS-CoV-2 receptor-binding domain in stably-transformed rice plants for developing country applications'. Plant Biotechnol J. 21, 6: 1094-1096.
- Basallo O, Perez L, Lucido A, et al. 2023, 'Changing terpenoid biosynthesis in rice through synthetic biology'. Frontiers in Plant Science, 14.1133299.