My career revolves around the application of bioinformatics tools to biological problems. My Ph.D. was about the study of the protein structure principles underlying function, a work that I extended during my stay at the NIH (1993-1997) and the UCL (1997-2000). This topic is at the core of my subsequent activities as ICREA researcher (PCB, 2001-2009; IBMB-CSIC, 2009-2012), although it has gradually evolved towards the study of pathological mutations. In 2012, I joined the Institute of Research at the Vall d'Hebron Hospital (VHIR), to increase the applicability of our work, and bring it closer to healthcare professionals and patients. As part of this effort, we are trying to involve all stakeholders in the health system, including companies.