Dr. Muro obtained her PhD in Sciences from Universidad Autónoma de Madrid, then was a Research Assistant Professor in Pharmacology in the University of Pennsylvania, and then a Tenured Associate Professor in the University of Maryland. Since November 2017, she is an ICREA Professor in the Institute for Bioengineering of Catalonia. She has published 98 articles and chapters in drug delivery and received awards from the Controlled Release Society, the American Society for Nanomedicine, has been a member of the USA NIH Nanomedicine Study Section and is an elected Fellow of the American Institute for Medical and Biological Engineering.
Research interests
Dr. Muro's research sits at the interface between cellular biology, nanotechnology, and drug delivery. She studies the biological mechanisms ruling how our tissues transport cargoes within our bodies and applies this knowledge to design of nanodevices for delivery of therapeutics to specific disease sites. Focusing on genetic conditions that cause metabolic, neurodegenerative and cardiovascular syndromes, as well as on a new transport pathway she helped discover, her goal is to gain efficient access within the body and its cells, to enable effective treatment of these life-threatening disorders.
Selected publications
- Placci M, Giannotti MI & Muro S 2023, 'Polymer-based drug delivery systems under investigation for enzyme replacement and other therapies of lysosomal storage disorders', Advanced Drug Delivery Reviews, 197, 114683.
- Nong J, Glassman PM, Myerson JW, et al. 2023, 'Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain', Acs Nano, 17, 14, 13121 - 13136.
- Loeck M, Placci M & Muro S 2023, 'Effect of acid sphingomyelinase deficiency in type A Niemann-Pick disease on the transport of therapeutic nanocarriers across the blood-brain barrier', Drug Delivery And Translational Research, AHEAD
- del Moral, Maria; Loeck, Maximilian; Muntimadugu, Eameema; Vives, Guillem; Pham, Vy; Pfeifer, Peter; Battaglia, Giuseppe; Muro, Silvia; Andrianov, Alexander K. 2023, 'Role of the Lactide:Glycolide Ratio in PLGA Nanoparticle Stability and Release under Lysosomal Conditions for Enzyme Replacement Therapy of Lysosomal Storage Disorders', Journal Of Functional Biomaterials, 14, 9, 440.
Selected research activities
Editor:
-Special Issue + editorial remark: Lysosomal Therapies and Drug Delivery Strategies. Adv Drug Deliv Revs.
Talks:
-Cellular transport and new enzyme replacement strategies (Sep. 2023) Annual Conference, Spanish Society for Acid Sphingomyelinase Deficiency, Madrid, Spain.
-Drug delivery: fundamental aspects and applications (Mar. 2023) Annual Retreat, Bioengineering Undergraduate Program, University of Barcelona, Spain.
-ICAM-1-mediated nano-biotechnology (Mar. 2023) Seminar series, Molecular Biotechnology Master Program, University of Barcelona, Spain.
Conferences:
-Transcytosis of anti-ICAM-1 nanoparticles in a model of the lung endothelium. (2023) Annual Symposium, Institute for Bioengineering of Catalonia, Barcelona, Spain.
Honors:
-Scientific Advisory Board, Nocturna Therapeutics (2023) Barcelona, Spain.
-Nominated Full Member of the Sigma Xi, The Scientific Research Honor Society (2023) USA.