Ángel Raya

Centre de Medicina Regenerativa de Barcelona

Life & Medical Sciences

Ángel Raya is an ICREA Research Professor at the Center of Regenerative Medicine in Barcelona (CMRB). He obtained his MD in 1990 from the University of Valencia, Spain and a PhD degree from the same university in 1995 for studies carried out at the Department of Physiology and at the Department of Neurology, Mayo Clinic, Rochester, MN. He pursued postdoctoral training at the Instituto de Investigaciones Citológicas (currently, Centro de Investigación Príncipe Felipe) in Valencia, from 1995-2000. He then was a Research Associate (2000-2004) and a Senior Research Associate (2004-2006) in the Gene Expression Laboratory of the Salk Institute for Biological Studies, La Jolla, CA. He returned to Spain in 2006 and was the Scientific Coordinator at the CMRB until 2009, when he joined the Institute for Bioengineering of Catalonia (IBEC) as Group Leader of the Control of Stem Cell Potency group. In 2014 he was appointed Director at CMRB.


Research interests

Our research work aims to understand the tissue, cellular and molecular mechanisms that determine the regenerative response in certain species of vertebrates, as well as the genetic and epigenetic mechanisms that control cellular reprogramming. This phenomenon provides a link between the traditional study of epimorphic regeneration and the induced pluripotency strategies of regenerative medicine.

Selected publications

- Galvez-Monton C et al. 2017, 'Preclinical Safety Evaluation of Allogeneic Induced Pluripotent Stem Cell-Based Therapy in a Swine Model of Myocardial Infarction', Tissue Eng Part C Methods, 23, 11, 1, 736 - 744.

- Miquel-Serra X et al. 2017, ‘Generation of six multiple sclerosis patient-derived induced pluripotent stem cell lines’, Stem Cell Res, 24, 155 - 159.

- Ojosnegros S et al. 2017, 'Eph-ephrin signaling modulated by polymerization and condensation of receptors', P Natl Acad Sci USA, 114: 13188-13193.

- Kuebler B et al. 2017, 'Generation of integration-free induced pluripotent stem cell lines derived from two patients with X-linked Alport syndrome (XLAS)', Stem Cell Res, 25: 291-295.

- Kuebler B et al. 2017, ‘Integration-free induced pluripotent stem cells derived from a patient with autosomal recessive Alport síndrome (ARAS)’, Stem Cell Res, 25: 1-5.

- Tekeli I et al. 2017, 'Fate predetermination of cardiac myocytes during zebrafish heart regeneration', Open Biol, 7: 170116.

- Pulecio J et al. 2017, 'CRISPR/Cas9-Based Engineering of the Epigenome', Cell Stem Cell, 21, 4, 431 - 447.

- Calatayud C et al. 2017, 'Modeling the genetic complexity of Parkinson's disease by targeted genome edition in iPS cells', Curr Opin Genet Dev, 46, 123 - 131.

- Martorell L et al. 2017, 'Advanced cell-based modeling of the royal disease: characterization of the mutated F9 mRNA', J Thromb Haemost​, 15, 11, 2188 - 2197.


Selected research activities

Keynote speaker

Symposium Romanian Society Biochem Mol Biol, Timisoara 06/17

IBMB Xmas Meeting, 12/17

Invited speaker

CABIMER Seminar Series, Sevilla 03/17

BIONAND 2017 Conference Series, Málaga 03/17

Escola de Fonseca, Santiago 05/17

sciBAC 2017, León 07/17

ETPN 2017, Málaga 10/17