Eduardo Eyras

Universitat Pompeu Fabra (UPF)

Life & Medical Sciences

Eduardo Eyras is ICREA Research Professor since January 2005. After graduating in Physics (U. of Granada, 1995) he did a PhD (U. of Groningen, The Netherlands, 1999) and postdoc (U. of Cambridge, UK)  in Theoretical Physics (1999-2001). During this period, he published 15 articles, which accumulate more than 900 citations. In 2001, Eyras joined the Wellcome Trust Sanger Institute, Cambridge, UK (2001-2004), where he developed one of the first methods to predict splicing variants from RNA expression data and participated in the analyses of the human, mouse and rat genomes. During 2004 he contributed to the analyses of alternative splicing in the chicken and cow genome genomes. Since 2007, Eyras has been organizer of the RNA workshop of the ISMB conference. In 2008, he was awarded a Young Investigator Grant of the EURASNET network and in 2013 he was a visiting professor at the U. of Toronto.

Research interests

Our group works on the development of computational tools to study mechanisms of RNA processing and its role in disease. In particular, we have a strong focus on the study of RNA splicing regulation and the role of RNA splicing in rare diseases and cancer.

Selected publications

– Sebestyen E, Singh B, Minana B, Pages A, Mateo F, Pujana MA, Valcarcel JEyras E 2016, ‘Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks’, Genome Research, 26, 6, 732 – 744.

– Trincado JL, Sebestyén E, Pagés A & Eyras E 2016, ‘The prognostic potential of alternative transcript isoforms across human tumors’, Genome Med., 8(1):85.

– Falaleeva M, Pages A, Matuszek Z, Hidmi S, Agranat-Tamir L, Korotkov K, Nevo Y, Eyras E, Sperling R, Stamm S 2016, ‘Dual function of C/D box small nucleolar RNAs in rRNA modification and alternative pre-mRNA splicing’, Proceedings Of The National Academy Of Sciences Of The United States Of America, 113, 12, E1625 – E1634.

– Llorian M, Gooding C, Bellora N, Hallegger M, Buckroyd A, Wang X, Rajgor D, Kayikci M, Feltham J, Ule J, Eyras E & Smith CWJ.2016, ‘The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators’, Nucleic Acids Research, 44, 18, 8933 – 8950.

– Rodor J, Pan Q, Blencowe BJ, Eyras E & Caceres JF 2016, ‘The RNA-binding profile of Acinus, a peripheral component of the exon junction complex, reveals its role in splicing regulation’, Rna, 22, 9, 1411 – 1426.

– Martin S, Bellora N, Gonzalez-Vallinas J, Irimia M, Chebli K, de Toledo M, Raabe M, Eyras E, Urlaub H, Blencowe BJ & Tazi J 2016, ‘Preferential binding of a stable G3BP ribonucleoprotein complex to intron-retaining transcripts in mouse brain and modulation of their expression in the cerebellum’, Journal Of Neurochemistry, 139, 3, 349 – 368.