Following study in Astronomy and Physics, I obtained my PhD (1986) in Molecular & Laser-Physics at the University of Nijmegen (the Netherlands), on microwave-laser double resonance molecular-beam spectroscopy. After research in non-linear optics of organic materials, integrated optics, atomic force and near-field optical microscopy, since 1997 full Professor in Applied Optics at MESA+ Institute for NanoTechnology, University of Twente (the Netherlands) with focus on single molecule detection and scanning probe technology. In 2005, attracted by the Catalan quality-based science policy, I started as ICREA Research Professor and senior group leader at ICFO - the Institute of Photonic Sciences, within The Barcelona Institute of Science & Technology; also I am Head Academic Programs at ICFO. I coordinate the Spanish CONSOLIDER program NanoLight.es. Recipient of 2003 Körber European Science Award, 2010 City of Barcelona Prize; ERC Advanced Grants in 2010 and 2015.