Xavier Trepat

Xavier Trepat

Institut de Bioenginyeria de Catalunya

Engineering Sciences

Xavier Trepat received a BSc in Physics in 2000 and a BSc in Engineering in 2001. In 2004 he obtained his PhD from the Medical School at the University of Barcelona. He then joined the Program in Molecular and Integrative Physiological Sciences at Harvard University as a postdoctoral researcher. In 2008 he became a "Ramón y Cajal" researcher at the University of Barcelona and in January 2011 an ICREA Research Professor at the Institute for Bioengineering of Catalonia (IBEC). He is Group Leader of the Integrative Cell and Tissue Dynamics research line at IBEC. In 2015, he won the Banc de Sabadell Award for Biomedical Research and, in 2021, the "Constantes y Vitales" award from A3Media. In 2018, he was elected EMBO Member.

Research interests

We aim at understanding how physical forces and molecular control modules cooperate to drive biological function. We develop new technologies to map and perturb the main physical properties that determine how cells and tissues grow, move, invade and remodel. By combining this physical information with systematic molecular perturbations and computational models we explore the principles that govern the interplay between chemical and physical cues in living tissues. We study how these principles are regulated in physiology and development, and how they are derailed in cancer.

Selected publications

- Conti S, Venturini V, Cañellas-Socias A, Cortina C, Abenza JF, Attolini CSO, Guerra EM, Xu CK, Li JH, Rossetti L, Stassi G, Roca-Cusachs P, Diz-Muñoz A, Ruprecht V, Guck J, Batlle E, Labernadie A & Trepat X 2024, 'Membrane to cortex attachment determines different mechanical phenotypes in LGR5+and LGR5-colorectal cancer cells', Nature communications, 15 - 1 -3363.
- Kennedy KE, Abenza JF, Rossetti L, Trepat X, Villoslada P, Garcia-Ojalvo J 2024, 'Parametric modeling of mechanical effects on circadian oscillators', Chaos, 34 - 1 - 013135.
- Vercruysse E, Brückner DB, Gómez-González M, Remson A, Luciano M, Kalukula Y, Rossetti L, Trepat X, Hannezo E, Gabriele S 2024, 'Geometry-driven migration efficiency of autonomous epithelial cell clusters', Nature physics, 20-1492-1500.
- Rossetti L, Grosser S, Abenza JF, Valon L, Roca-Cusachs P, Alert R & Trepat X 2024, 'Optogenetic generation of leader cells reveals a force-velocity relation for collective cell migration', Nature physics, 20 - 1659-1669.
- Faure LM, Gómez-González M, Baguer O, Comelles J, Martínez E, Arroyo M, Trepat X & Roca-Cusachs P 2024, '3D Micropatterned Traction Force Microscopy: A Technique to Control 3D Cell Shape While Measuring Cell-Substrate Force Transmission', Advanced science, 11-46.
- Nelson CM, Xiao B, Wickström SA, Dufrêne YF, Cosgrove DJ, Heisenberg CP, Dupont S, Shyer AE, Rodrigues AR, Trepat X & Diz-Muñoz A. 2024, 'Mechanobiology: Shaping the future of cellular form and function', Cell, vol. 187, no.11, pp 2652-2656