Salvador Aznar Benitah

Salvador Aznar Benitah

Institut de Recerca Biomèdica

Life & Medical Sciences

Salvador Aznar Benitah is a group leader at the Institute for Research in Biomedicine (IRB Barcelona). He holds a BSc/MSc in Biochemistry from the University of McGill (Montreal, Canada), from where he moved to the Biomedical Research Institute (Madrid, Spain) to obtain a PhD in Molecular Biology. His professional career continued at the London Research Institute (Cancer Research UK) in the laboratory of Prof. Fiona Watt where he acquired extensive knowledge on adult stem cells. He started as a Junior ICREA researcher at the CRG in 2007 where he studied the role of adult stem cells in tissue homeostasis and cancer. Since September 2012 he is an ICREA Research Professor. In September 2013 he became a Senior Researcher in the Oncology Department at the Institute for Research in Biomedicine (IRB Barcelona).

Research interests

Our global aim is to characterize the molecular pathways that regulate the behaviour of normal stem cells during homeostasis, and how they become deregulated during carcinogenesis and ageing. Research Lines: - What intrinsic mechanisms regulate adult stem cell function, and how are they deregulated during ageing and cancer? - How do adult stem cells communicate with their local environment and how is the system coordinated to dictate stem cell function? - What systemic cues communicate with adult stem cells and how do distant adult stem cells coordinate their function at the level of the whole organism? - How does deregulation of pathways that control stem cell behaviour contribute to the maintenance and progression of carcinomas?

Selected publications

- Kumar A, Vaca-Dempere M, Mortimer T, Deryagin O, Smith JG, Petrus P, Koronowski KB, Greco CM, Segales J, Andres E, Lukesova V, Zinna VM, Welz PS, Serrano AL, Perdiguero E, Sassone-Corsi P, Benitah SA & Munoz-Canoves P 2024, 'Brain-muscle communication prevents muscle aging by maintaining daily physiology', Science, 384 - 6695 - 563 - 572.
- Pascual G, Majem B & Benitah SA 2024, 'Targeting lipid metabolism in cancer metastasis', Biochimica et biophysica acta (BBA) - Reviews on cancer, 1879 - 1 - 189051.
- Berbegal-Sáez P, Gallego-Landin I, Macía J, Alegre-Zurano L, Castro-Zavala A, Welz PS, Benitah SA & Valverde O 2024, 'Lack of Bmal1 leads to changes in rhythmicity and impairs motivation towards natural stimuli', Open biology, 14 -240051.
- Pascual G & Benitah SA 2024, 'Lipids in the tumor microenvironment: immune modulation and metastasis', Frontiers in oncology, 14 -1435480.
- Bigas C, Martin J, Majem B & Aznar-Benitah S 2024, 'Maternal overnutrition and increased risk of intergenerational liver disease and cancer targeting epigenetic mechanisms', Febs open bio, 14 -12 - 12.
- Caeiro LD, Nakata Y, Borges RL, Zha MS, Garcia-Martinez L, Banuelos CP, Stransky S, Liu T, Chan HL, Brabson J, Domínguez D, Zhang YS, Lewis PW, Benitah SA, Cimmino L, Bilbao D, Sidoli S, Wang Z, Verdun RE & Morey L 2024, 'Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma', Genes & development, 38 - 1-2 - 46 - 69.