Pablo  Menéndez

Pablo Menéndez

Institut de Recerca contra la Leucèmia Josep Carreras

Life & Medical Sciences

Born in Avilés, Asturias, in 1974. Biochemist by University of Salamanca (1997) and PhD in Medicine (Hematology) by the same University in 2002, under the supervision of Prof. Alberto Orfao and Prof. Jesus San Miguel. Postdoctoral training in stem cell biology (Mick Bhatia Laboratory, London, ON, Canada; 2002-2005) and in childhood leukemia (Mel Greaves Laboratory, London, UK; 2005-2007). In 2007, I was appointed Director of the Andalusian Stem Cell Bank, and was leading my own lab at CIBM (Granada, Spain) until July 2011 when I moved to GENyO (Granada, Spain) as Principal Invesigator. In June 2013 I was appointed ICREA Research Professor and coordinator of Clinic campus of The Josep Carreras Leukemia Research Institute (Barcelona).

Research interests

1.-Understanding the pathogenesis and cellular origin of MLL-rearranged and MLL-germline Acute Lymphoblastic Leukemia in children.  2.-Leukemic cell-bone marrow environment interactions and targeted therapies in Acute Myeloid Leukemia and therapy resistance. 3.- Adoptive T-cell-based CAR immunotherapy for B-cell, T-cell ALL, AML and bone sarcomas. 4.-Deciphering the intrinsic determinants and signaling pathways underlying hematopoietic from human pluripotent stem cells.  

Selected publications

- Tomás-Daza L, Rovirosa L, López-Martí P, et al. 2023, 'Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution', Nature Comm, 14(1), 268.

- Meyer C, Larghero P, Almeida Lopes B, et al.2023, 'The KMT2A recombinome of acute leukemias in 2023', Leukemia, 37(5):988-1005.

- Bueno C, Torres-Ruiz R, Molina O, Velasco T, Martínez A, Roy A, Marschalek R, Milne T, Fraga MF, Tejedor R & Menendez P* 2023, 'A human genome editing-based MLL::AF4 B-cell ALL model recapitulates key cellular and molecular leukemogenic features', Blood, 142(20):1752-1756.
- Mensali N, Koeksal H, Joaquina S, Wernhoff P, et al. 2023, 'ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma', Nature Communications, 14, 1, 3375.

- Velasco P, Bautista F, Rubio A, et al. 2023, 'The relapsed acute lymphoblastic leukemia network (ReALLNet): a multidisciplinary project from the spanish society of pediatric hematology and oncology (SEHOP)Fronteirs Pediatrics, 11, 1269560.

- Marin-Bejar O, Romero-Moya D, Rodriguez-Ubreva J, et al. 2023, 'Epigenome profiling reveals aberrant DNA methylation signature in GATA2 deficiency', Haematologica, 108, 9, 2551 - 2557.

- Velasco-Hernandez T & Menendez P 2023, 'Long non-coding RNAs emerge as a novel prognostic indicator in pediatric acute myeloid leukemia', Translational Pediatrics, TP-23-351.