Maria Carolina Florian

Maria Carolina Florian

Institut d'Investigació Biomèdica de Bellvitge

Life & Medical Sciences

M. Carolina Florian received her PhD in 2008 from the University of Milan (Italy) where she trained in neuroendocrinology investigating mechanisms of neuroblastoma migration and invasion. Afterwards, she moved to the University of Ulm (Germany) for her postdoctoral training (2009-2015) on hematopoiesis and hematopoietic stem cell biology. During the postdoc, she also trained as visiting scientist (2011-2012) at the Experimental Hematology Department of Cincinnati Children’s Hospital (Cincinnati, USA).

In 2016, Dr. Florian was awarded an Emmy Noether grant (DFG) to lead her independent research group on Epigenetics of Stem Cell Aging at the Institute of Molecular Medicine, University of Ulm (Germany). In 2018, she was appointed by the Program for the Clinical Translation of Regenerative Medicine in Catalonia (P-CMRC) and the Program of Regenerative Medicine at IDIBELL (Barcelona, Spain) as group leader. In 2023, she became ICREA Research Professor (ICREA).

Research interests

Dr. Florian's research in the past years strongly challenged the concept that aging is an irreversible process. Since 2016, in her team they investigate the role of epigenetics and of the stem cell microenvironment in driving aging of somatic stem cells. Dr. Florian’s lab focuses on understanding cellular and molecular mechanisms of somatic stem cell aging, supporting the development of new therapeutic strategies to preserve the regenerative capacity of stem cells over time and to limit or prevent the development of age-related disorders and extend lifespan.

Selected publications

- Florian MC 2024, 'Powerful microscopy reveals blood-cell production in bone marrow'. Nature 627 (8005), 741-742.
- Matteini F, Montserrat-Vazquez S & Florian MC 2024, 'Rejuvenating aged stem cells: therapeutic strategies to extend health and lifespan'. FEBS letters, 589, 22, 2776-2787.
- Thambyrajah R, Maqueda M, Neo WH, Imbach K, Guillén Y, Grases D, Fadlullah Z, Gambera S, Matteini F, Wang XA, Calero-Nieto FJ, Esteller M, Florian MC, Porta E, Benedito R, Göttgens B, Lacaud G, Espinosa L, Bigas A 2024, 'Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate', Nature communications, 15, 1, 1604.
- Cruzado JM, Manonelles A, Rayego-Mateos S, Doladé N, Amaya-Garrido A, Varela C, Guiteras R, Mosquera JL, Jung MCL, Codina S, Martinez-Valenzuela L, Draibe J, Couceiro C, Vigues F, Madrid A, Florian MC, Ruiz-Ortega M, Sola A 2024, 'Colony stimulating factor-1 receptor drives glomerular parietal epithelial cell activation in focal segmental glomerulosclerosis', Kidney international, 106 - 1 - 67 - 84.

Selected research activities

CONGRESS AND MEETING ORGANISATION
  • RegenBell Symposium (2024): it aims to cover a wide range of topics, including stem cell biology, development, adult stem cells and clinical applications of regenerative medicine
  • Hematology in Barcelona: Biology of Disease (2024): The event brought together 135 registered participants from the scientific community dedicated to the study of blood biology.
 
PRESENTATIONS (selected)
  • Invited speaker at FASEB conference “Transcription, Chromatin, and Epigenetics in Aging” Florida, USA, Sep. 2024
  • Invited speaker at the 46. Congreso de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM) A Coruña, ES, Sep. 2024
  • Invited speaker at the 38th Congress of the International Society of Blood Transfusion (ISBT) Barcelona, ES, Jun. 2024
  • Selected speaker at the Gordon Meeting, System Aging 2024 Barcelona, ES, Jun. 2024
  • Invited speaker at the Global Female Leader summit 2024 Frankfurt, DE, May. 2024