M. Mar Albà

M. Mar Albà

Institut Hospital del Mar d'Investigacions Mèdiques

Life & Medical Sciences

Mar Albà graduated in Biological Sciences at the University of Barcelona (UB), and obtained her PhD at the same University in 1997. During 1997-1999 she studied for the MSc in Bioinformatics and Molecular Modeling at Birkbeck College while working as a postdoctoral researcher in the group of John Hancock at the MRC Clinical Research Centre, in London. Later she joined the group led by Paul Kellam at University College London to develop new computational tools to study herpesvirus evolution and function. She was awarded a Ramón y Cajal tenure track position in 2002 to work at Universitat Pompeu Fabra (UPF). In 2005 she was appointed ICREA Research Professor. She works at the Hospital del Mar Research Institute (IMIM) and teaches bioinformatics at Universitat Pompeu Fabra. She has directed 10 doctoral thesis and is author of more than 80 publications.

Research interests

As a result of a continuous process of gene birth and death, the genomes from different species contain different sets of genes. Some of these genes encode new functional proteins and facilitate the adaptation to a changing environment. Some new genes originate by gene duplication, but others emerge de novo from previously non-coding genomic sequences. We study the different mechanisms of gene birth using a combination of comparative genomics, high throughput RNA sequencing (RNA-Seq) and ribosome profiling data (Ribo-Seq). We have shown that transcription and translation are pervasive and result in many putative precursors of novel proteins. We are aiming at a quantitative and qualitative description of the still poorly understood process of de novo gene formation.

Selected publications

– Ruiz-Orera J, Villanueva-Canas JL & Albà MM 2020, ‘Evolution of new proteins from translated sORFs in long non-coding RNAs’, Experimental Cell Research, 391, 1, 111940 – 111940.

– Reixachs-Solé M, Ruiz-Orera J, Albà MM & Eyras E 2020, ‘Ribosome profiling at isoform level reveals evolutionary conserved impacts of differential splicing on the proteome’, Nature Communications, 11: 1768.

– Hong SY, Sun B, Straub D, Blaakmeer A, Mineri L, Koch J, Brinch-Pedersen H, Holme IB, Burow M, Lyngs Jørgensen HJ, Albà MM & Wenkel S 2020, ‘Heterologous microProtein expression identifies LITTLE NINJA, a dominant regulator of jasmonic acid signaling’Proceedings of the National Academy of Sciences USA, 117, 42, 26197 – 26205.

Selected research activities

Supervision of PhD thesis by William R. Blevins, defended on January 17 2020: Evolutionary dynamics of transcriptional and translational regulation in yeast.