We are interested in bioinspired surfaces and interfaces for prevention of disease and promotion of tissue repair and regeneration. Using inspiration from nature’s molecules and structures, we design, modify and characterize bioinstructive materials tthat control supramolecular assembly, spatial-temporal bioactive responses and cellular colonization selectively to prevent infection and promote regeneration for dental, oral and orthopedic therapies. We further decipher mechanisms of bio/non-bio interactions and enable materials based on systematically mining and selecting recombinant and natural polymers and peptides. Tailoring physicochemical cues at bio interfaces we develop bioinstructive materials through harnessing extracellular matrix components and biological dynamic reciprocal interactions; including non-classical biomimetic processes of biomineralization for surfaces and scaffolds; and materials/biological agents to induce mucosal and hard tissue attachment.