Salvador Aznar Benitah

Salvador Aznar Benitah

Institut de Recerca Biomèdica

Life & Medical Sciences

Salvador Aznar Benitah is a group leader at the Institute for Research in Biomedicine (IRB Barcelona). He holds a BSc/MSc in Biochemistry from the University of McGill (Montreal, Canada), from where he moved to the Biomedical Research Institute (Madrid, Spain) to obtain a PhD in Molecular Biology. His professional career continued at the London Research Institute (Cancer Research UK) in the laboratory of Prof. Fiona Watt where he acquired extensive knowledge on adult stem cells. He started as a Junior ICREA researcher at the CRG in 2007 where he studied the role of adult stem cells in tissue homeostasis and cancer. Since September 2012 he is an ICREA Research Professor. In September 2013 he became a Senior Researcher in the Oncology Department at the Institute for Research in Biomedicine (IRB Barcelona). In 2018 he was appointed as the Coordinator of the Aging and Metabolism Department at the IRB Barcelona.

Research interests

Our global aim is to characterize the molecular pathways that regulate the behaviour of normal stem cells during homeostasis, and how they become deregulated during carcinogenesis and ageing. Research Lines: - What intrinsic mechanisms regulate adult stem cell function, and how are they deregulated during ageing and cancer? - How do adult stem cells communicate with their local environment and how is the system coordinated to dictate stem cell function? - What systemic cues communicate with adult stem cells and how do distant adult stem cells coordinate their function at the level of the whole organism? - How does deregulation of pathways that control stem cell behaviour contribute to the progression of carcinomas, specially during metastasis?

Selected publications

- Moiseeva V, Cisneros A, Sica V, et al. 2023, 'Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration', Nature, 613, 169-178.

- Solá P, Mereu E, Bonjoch J et al. 2023, 'Targeting lymphoid-derived IL-17 signaling to delay skin aging', Nature Aging, 3, 688-704.
- Redondo-Munoz M, Rodriguez-Baena FJ, Aldaz P, et al. 2023, 'Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy', Nature Metabolism, 2023.

- Smith JG, Koronowski KB, Mortimer T, et al. 2023, 'Liver and muscle circadian clocks cooperate to support glucose tolerance in mice', Cell Reports, 42, 6, 112588.

Selected research activities

-Obtained an ERC Proof of Concept
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Obtained an AECC Coordinated Grant (I coordinated it)
-Appointed member of the EMBO Council
-Appointed member of the AACR (American Association for Cancer Research) Organizing Committee
-Appointed Coordinator of the Aging and Metabolism Department at IRB Barcelona
-Organizer of the Keystone Aging meeting
-Organizer of the Gordon Research Conference on Epithelial Stem Cells