Salvador Aznar Benitah

Salvador Aznar Benitah

Institut de Recerca Biomèdica

Life & Medical Sciences

Salvador Aznar Benitah is a group leader at the Institute for Research in Biomedicine (IRB Barcelona). He holds a BSc/MSc in Biochemistry from the University of McGill (Montreal, Canada), from where he moved to the Biomedical Research Institute (Madrid, Spain) to obtain a PhD in Molecular Biology. His professional career continued at the London Research Institute (Cancer Research UK) in the laboratory of Prof. Fiona Watt where he acquired extensive knowledge on adult stem cells. He started as a Junior ICREA researcher at the CRG in 2007 where he studied the role of adult stem cells in tissue homeostasis and cancer. Since September 2012 he is an ICREA Research Professor. In September 2013 he became a Senior Researcher in the Oncology Department at the Institute for Research in Biomedicine (IRB Barcelona).

Research interests

Our global aim is to characterize the molecular pathways that regulate the behaviour of normal stem cells during homeostasis, and how they become deregulated during carcinogenesis and ageing. Research Lines: - What intrinsic mechanisms regulate adult stem cell function, and how are they deregulated during ageing and cancer? - How do adult stem cells communicate with their local environment and how is the system coordinated to dictate stem cell function? - What systemic cues communicate with adult stem cells and how do distant adult stem cells coordinate their function at the level of the whole organism? - How does deregulation of pathways that control stem cell behaviour contribute to the maintenance and progression of carcinomas?

Selected publications

- Mortimer T, Smith JG, Muñoz-Cánoves P, Benitah SA 2025, 'Circadian clock communication during homeostasis and ageing', Nature reviews molecular cell biology, 26 - 4 - 314 - 331.
- Duan JY, Karri SS, Forouzesh K, Mortimer T, Plikus MV, Benitah SA, Takahashi JS & Andersen B 2025, 'Designing and Evaluating Circadian Experiments on Mouse Skin', Journal of investigative dermatology, 145 - 3 - 484 - 493.
- Bigas C, Martin J, Majem B & Aznar-Benita S 2025, 'Unraveling the connection between maternal overnutrition and higher risk of liver disease in offspring', Febs open bio, 15 - - 19 - 20.
- Aznar-Benitah S, Solanas G, Bonjoch J & Posas G 2025, 'The role of Schwann cells in aging-dependent tissue decline', Febs open bio, 15 - 24 - 24.
- Sica V, Smith JG, Deryagin O, Andrés E, Lukesova V, Egg M, Cabezas-Wallscheid N, Benitah SA, Serrano AL, Perdiguero E & Muñoz-Cánoves P 2025, 'The central clock drives metabolic rhythms in muscle stem cells', Cell reports, 44 - 10 - 116354.
- Pauli C, Kienhöfer M, Blank MF, Begik O, Rohde C, Zimmermann SMN, Werner L, Heid D, Xu F, Weidenauer K, Delaunay S, NKrall N, Trunk K, Zhao D, Zhou F, Llovera L, Ollivier A, Heit-Mondrzyk A, Platzbecker U, Baldus C, Serve H, Bornhäuser M, Broberg Vågbø C, Aznar Benitah S, Krijgsveld J, Novoa EM, Müller-Tidow C & Frye M 2025, 'Disrupting tRNA modifications to target mitochondrial vulnerabilities in drug-resistant leukemia cells', Blood, 146 - 20 - 2443–2456.