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Eduard Batlle

Eduard Batlle

Institut de Recerca Biomèdica

Life & Medical Sciences

Eduard Batlle joined the Institute for Research in Biomedicine (IRB Barcelona) as ICREA Research Professor and Head of the Oncology Program in 2004. His research activity has focused on the mechanisms that drive colorectal cancer (CRC) initiation and progression. Amongst other findings, his research originally identified the transcription factor Snail as a repressor of E-Cadherin gene expression during the EMT (2000); the connection between intestinal stem cells and CRC (2002-2011); and more recently a key role for TGF-beta signaling in stromal cells during metastatic colonization (2012-2015). His track record has been recognized through several awards/honors such as the Sabadell Banc Award for Biomedical Research (2010), Josef Steiner Award (2013), ERC Starting and Advanced Grants (2007, 2013, 2019), the Pezcoller foundation-EACR award (2014), the Lilly Foundation Award (2016) and the King Jaume-I award in Medicine (2021). 

Research interests

The inner layer of the intestinal tube, the intestinal epithelium, is in a constant process of renewal. Hundreds of millions of terminally differentiated intestinal cells are replaced by new cells every day during the life of an adult organism. This tremendous regenerative power is ultimately sustained by a small population of intestinal stem cells. It is believed that alterations in the functioning of intestinal stem cells account for the pathophysiology of various bowel disorders. Our laboratory studies the connection between the biology of Intestinal Stem Cells and Colon Cancer. We are also interested in the process of metastasis, the cause of death of most colorectal cancer (CRC) patients. Neither conventional chemotherapy nor current targeted therapies offer significant benefits once the disease has spread to distant organs. Furthermore, current CRC staging based on histopathology and imaging has a limited ability to predict the evolution of the disease. We have recently discovered that vast majority of genes that distinguish poor prognosis CRC subtypes are expressed by stromal cells rather than by epithelial tumor cells. We proposed that metastasis relies on a tumor cell non-autonomous program driven by TGF-beta in the tumor microenvironment.

Selected publications

– Kasashima H, Duran A, Martinez-Ordoñez A, Nakanishi Y, Kinoshita H, Linares JF, Reina-Campos M, Kudo Y, L’Hermitte A, Yashiro M, Ohira M, Bao F, Tauriello DVF, Batlle E, Diaz-Meco MT & Moscat J 2021, ‘Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population‘. Developmental Cell. Volume 56, Issue 1, Pages 95-110.

– Kasashima H, Duran A, Cid-Diaz T, Muta Y, Kinoshita H, Batlle E, Diaz-Meco MT, Moscat J. 2021 ‘Mouse model of colorectal cancer: orthotopic co-implantation of tumor and stroma cells in cecum and rectum’. STAR Protoc. vol 22;2(1):100297. doi: 10.1016/j.xpro.2021.100297.

– Pérez-González C, Ceada G, Greco F, Matejčić M, Gómez-González M, Castro N, Menendez A, Kale S, Krndija D, Clark AG, Gannavarapu VR, Álvarez-Varela A, Roca-Cusachs P, Batlle E, Vignjevic DM, Arroyo M, Trepat X. 2021.‘Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration’. Nat Cell Biol. vol.23(7):745-757. doi: 10.1038/s41556-021-00699-6.

– Vera-Otarola J, Castillo-Vargas E, Angulo J, Barriga FM, Batlle E, Lopez-Lastra M. 2021. The viral nucleocapsid protein and the human RNA-binding protein Mex3A promote translation of the Andes orthohantavirus small mRNA’.  PLoS Pathog.;17(9):e1009931.

– Nieto P, Elosua-Bayes M, Trincado JL, Marchese D, Massoni-Badosa R, Salvany M, Henriques A, Nieto J, Aguilar-Fernández S, Mereu E, Moutinho C, Ruiz S, Lorden P, Chin VT, Kaczorowski D, Chan CL, Gallagher R, Chou A, Planas-Rigol E, Rubio-Perez C, Gut I, Piulats JM, Seoane J, Powell JE, Batlle E, Heyn H. 2021. A single-cell tumor immune atlas for precision oncology.’ Genome Res. 31, 10, 1913 – 1926.

– Tauriello DVF, Sancho E, Batlle E. 2021 ‘Overcoming TGFβ-mediated immune evasion in cancer’, Nature Reviews Cancer. Oct 20. doi: 10.1038/s41568-021-00413-6.

Selected research activities

– King Jaume-I award in Medicine 2021

ICREA Memoir 2021