Andrea Cerutti, MD, PhD, is an ICREA Research Professor since 2010 and leads the B Cell Biology Group at FIMIM, which is a research center located in the PRBB complex. He serves as grant reviewer for the European Research Council and the National Institutes of Health, and as manuscript reviewer for journals such as Cell, Cell Host&Microbe, Science, Nature, Immunity, Nature Immunology, Nature Medicine, Nature Communications, The Journal of Experimental Medicine, Proceedings of the National Academy of Sciences, Cell Reports, etc. He is a member of The American Society for Clinical Investigation, The American Association of Immmunologists, and The Henry Kunkel Society and serves as Associate Editor of Mucosal Immunology. He contributed to the organization of 2014 and 2016 Keystone Symposia meetings, published over 130 research articles in immunology journals, and lectures in international meetings as well as American and European universities.
The splenic marginal zone and gut mucosa can be viewed as interfaces between the immune system and the circulation or external environment, respectively. My group studies how B cells strategically positioned in these “frontline” areas make antibodies against circulating or intraluminal antigens, including intestinal microbes. We are particularly interested in the mechanism whereby splenic stromal cells or splenic innate immune cells, including neutrophils, dendritic cells, macrophages and innate lymphoid cells, facilitate the activation of splenic marginal zone B cells. We are also analyzing how intestinal B cells generate antibodies to commensal bacteria and how these antibodies shape the composition of the gut microbiota. Finally, we study the alterations of B cells in patients with primary antibody deficiency, including selective IgA deficiency and common variable deficiency. Our research is relevant to infections, inflammation, autoimmunity, immunodeficiency, and vaccine development.
– Maglione PJ, Gyimesi G, Cols M, Radigan L, Ko HM, Weinberger T, Lee BH, Grasset EK, Rahman AH, Cerutti A, Cunningham-Rundles C 2019, ‘BAFF-driven B cell hyperplasia drives lung disease in comon variable immunodeficiency‘, JCI Insight, 4, 5, e122728.
– Perdiguero P, Martin-Martin A, Benedicenti O, Diaz-Rosales P, Morel E, Munoz-Atienza E, Garcia-Flores M, Simon R, Soleto I, Cerutti A, Tafalla C 2019, ‘Teleost IgD(+)IgM(-) B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles’, Cell Reports, 29, 13, 4223 – +.
– Galindo-Campos MA, Bedora-Faure M, Farres J, Lescale C, Moreno-Lama L, Martinez C, Martin-Caballero J, Ampurdanes C, Aparicio P, Dantzer F, Cerutti A, Deriano L & Yelamos J 2019, ‘Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function’, Cell Death And Differentiation, 26, 12, 2667 – 2681.
Selected research activities
ERC Evaluation Member, Panel LS6, ERC Consolidator Grant 2019, Step 1 (May 2019), Step 2 (October 2019).