Andrea Cerutti

Andrea Cerutti

Institut Hospital del Mar d'Investigacions Mèdiques

Life & Medical Sciences

Andrea Cerutti, MD, PhD, is an ICREA Research Professor since 2010 and leads the B Cell Biology Group at FIMIM, which is a research center located in the PRBB complex. He serves as grant reviewer for the European Research Council and the National Institutes of Health, and as manuscript reviewer for journals such as Cell, Cell Host&Microbe, Science, Nature, Immunity, Nature Immunology, Nature Medicine, Nature Communications, The Journal of Experimental Medicine, Proceedings of the National Academy of Sciences, Cell Reports, etc. He is a member of The American Society for Clinical Investigation, The American Association of Immmunologists, and The Henry Kunkel Society and serves as Associate Editor of Mucosal Immunology. He contributed to the organization of 2014 and 2016 Keystone Symposia meetings, published over 130 research articles in immunology journals, and lectures in international meetings as well as American and European universities.

Research interests

The splenic marginal zone and gut mucosa can be viewed as interfaces between the immune system and the circulation or external environment, respectively. My group studies how B cells strategically positioned in these "frontline" areas make antibodies against circulating or intraluminal antigens, including intestinal microbes. We are particularly interested in the mechanism whereby splenic stromal cells or splenic innate immune cells, including neutrophils, dendritic cells, macrophages and innate lymphoid cells, facilitate the activation of splenic marginal zone B cells. We are also analyzing how intestinal B cells generate antibodies to commensal bacteria and how these antibodies shape the composition of the gut microbiota. Finally, we study the alterations of B cells in patients with primary antibody deficiency, including selective IgA deficiency and common variable deficiency. Our research is relevant to infections, inflammation, autoimmunity, immunodeficiency, and vaccine development.

Selected publications

- Chen K; Magri G; Grasset EK & Cerutti A 2020, 'Rethinking mucosal antibody responses: IgM, IgG and IgD join IgA', Nature Reviews Immunology, vol. 20, no. 7, pp. 427-441.

- Grasset E & Cerutti A  2020, 'Mutations make gut antibodies promiscuous', Journal of Experimental Medicine, Vol. 217 No. 11 e20201340.

- Magri G & Cerutti A 2020, 'IgA Summons IgG to Take a Hit at HIV-1.', Cell Host & Microbe, vol. 27, no. 6, pp. 854 - 856.

- Yang C, Mogno I, Contijoch EJ, Borgerding JN, Aggarwala V, Li Z, Siu S, Grasset EK, Helmus DS, Dubinsky MC, Mehandru S, Cerutti A & Faith JJ 2020, 'Fecal IgA levels are determined by strain-level differences in Bacteroides ovatus and are modifiable by gut microbiota manipulation', Cell Host & Microbe, vol. 27, no. 3, pp 467-475.

- Grasset EK, Chorny A, Casas-Recasens S, Gutzeit C, Bongers G, Thomsen I, Chen L, He Z, Matthews DB, Oropallo MA, Veeramreddy P, Uzzan M, Mortha A, Carrillo J, Reis BS, Ramanujam M, Sintes J, Magri G, Maglione PG, Cunningham-Rundles C, Bram RJ, Faith J, Mehandru S, Pabst O, & Cerutti A 2020, 'Gut T cell–independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells', Science Immunology, 5, 49:eaat7117.  

Selected research activities

Reviewer, ERC Evaluation Panel LS7, ERC Starting Grant 2020, Step 2 (May 12th).