ICREA Research Professor and Senior Scientist at Centre for Genomic Regulation since Sep 2010. Acadèmica Corresponent Reial Acadèmia de Medicina de Catalunya since 2025. From 2009-2015 Honorary Associate Investigator at CNR. 2003-2010 Associate Investigator at TIGEM, Naples. 2004-2010 Lecturer at European School of Molecular Medicine. 1997-2000 Marie Curie Postdoc at IMP, Vienna. PhD in Cellular and Molecular Genetics, Univ. Federico II of Naples, 2000. Visiting Scientist in many Universities in USA. EMBO Young Investigator (YIP), 2003; Marie Curie Excellence Award, 2005; "Vanguardia de la Ciència" prize, 2014; City of Barcelona prize, 2015; EIC Women Leadership 2022. Professor Joaquín Barraquer Award 2023. She is Order of Merit of the Italian Republic: Knight, 2007. ERC Starting Grant awardee, 2009 and HFSP Grant awardee, 2010. EMBO Member since 2010. Coordinator of H2020 FET-Open Cellviewer and EcaBox. La Caixa Health Reacher awardee in 2018 and 2024.
Research interests
The main interests of the group are to dissect the mechanisms and factors that control somatic cell reprogramming and tissue regeneration in mammals. Computational approaches are employed to identify the key regulators and mechanisms underlying retinal regeneration in mammals and to translate these fundamental discoveries into applications such as cell therapies for retinal degeneration. An additional focus of the group is the study of chromatin organization and 3D genome folding in somatic, stem, and cancer cells, using an integrated and innovative methodology that combines state-of-the-art super-resolution microscopy with genomic approaches. AI-driven and computational methods are applied to analyze super-resolution imaging data in order to elucidate, identify, and reconstruct the biological functions observed in cells, tissues, and organs.
Selected publications
- González-Almela E, Castells-Garcia A, Le Dily F, Merino MF, Carnevali D, Cusco P, Di Croce L & Cosma MP 2025, 'Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijacking', Nature communications, 16 - 1 - 5313.
- Sebastian-Perez R, Nakagawa S, Tu XC, Aranda S, Pesaresi M, Gomez-Garcia PA, Alcoverro-Bertran M, Gomez-Vazquez JL, Carnevali D, Borràs E, Sabidó E, Martin L, Nissim-Rafinia M, Meshorer E, Neguembor MV, Di Croce L & Cosma MP 2025, 'SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state', Elife, 12 - RP87742.
- Merino MF, Cosma MP & Neguembor MV 2025, 'Super-resolving chromatin in its own terms: Recent approaches to portray genomic organization', Current opinion in structural biology, 92 -103021.
- Cosma MP 2025, 'The diffraction limit of light taken by storm', Nature reviews molecular cell biology.
- Rotkevich M, Viana C, Neguembor MV & Cosma MP 2025, 'Deep learning in chromatin organization: from super-resolution microscopy to clinical applications', Cellular and molecular life sciences, 82 - 1 - 323.
Selected research activities
Invited Speaker
ISSCR meeting Hong Kong, 11-14 June 2025
Genome Architecture in Cell Fate and Disease Gordon Research Conference, 15-20 June 2025.
2025 Cold Spring Harbor Asia Conference on Nuclear Architecture and Function, 1-4 September, Suzhou, China.
Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany 23rd January 2025.
Reial Acadèmia de Medicina de Catalunya, Barcelona, Spain, 28th January 2025. Shenzhen Bay Laboratory (SZBL), Shenzhen, China, 29th September 2025. Shenzhen Institute of Advanced Technology (SIAT), Shenzhen, China, 24th October 2025.